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妊娠期乳腺癌治疗(PDQ®)

妊娠期乳腺癌治疗概况

乳腺癌是一种在乳腺组织中形成恶性(癌)细胞的疾病。

乳房由腺叶和导管组成。每个乳房有15到20个腺叶。每个腺叶都有许多乳小叶。乳小叶的末端有几十个可以制造乳汁的腺泡。腺叶、乳小叶和腺泡由称为导管的细管连接。

女性乳房的解剖图。乳头和乳晕在乳房外侧。乳房内部的淋巴结、腺叶、乳小叶、导管和其他部分也显示出来。

每个乳房也有血管和淋巴管。淋巴管携带一种几乎无色的水状液体,叫做淋巴。淋巴管在淋巴结之间运送淋巴。淋巴结是遍布全身的豆状大小结构。它们过滤淋巴,储存有助于抵抗感染和疾病的白细胞。在腋窝(腋下)、锁骨上方和胸部的乳房附近都存在多组淋巴结。

有时乳腺癌发生在怀孕或刚刚分娩的妇女身上。

乳腺癌大约每3000次怀孕发生一次。最常见于32至38岁的女性。由于许多妇女选择推迟生育,怀孕期间新发乳腺癌病例的数量将会增加。

乳腺癌的症状包括乳房肿块或乳房中的其他改变。

这些和其他症状可能是由乳腺癌或其他疾病引起的。如果您有下列情况,请咨询您的医生:

  • 乳房或腋下有肿块或有增厚。
  • 乳房大小或形状的变化。
  • 乳房皮肤上的凹陷或皱褶。
  • 乳头向内凹入乳房。
  • 从乳头流出的液体,不是母乳,尤其是血性液体。
  • 乳房、乳头或乳晕(乳头周围皮肤的黑色区域)上有鳞状的、红色的或肿胀的皮肤。
  • 胸部的凹痕看起来像橘子皮,叫做橘皮样改变。
  • 孕妇或哺乳期妇女可能很难早期发现乳腺癌。

    在怀孕、哺乳或刚刚分娩的妇女中,乳房通常会变大、变软或有团块状。这是因为正常的荷尔蒙变化发生在怀孕期间。这些变化会使小肿块难以检测。乳房也可能变得更致密。在乳房致密的女性中,用乳房X光检查更难发现乳腺癌。因为这些乳房改变会延迟诊断,这些妇女通常在较晚的阶段发现乳腺癌。

    乳房检查应该是产前和产后护理的一部分。

    为了检测乳腺癌,孕妇和哺乳期妇女应该自己检查乳房。妇女还应定期在产前和产后接受临床乳房检查。如果你发现你的乳房有任何你不期望或担心的变化,就及时告诉医生。

    检查乳房的测试用于检测(发现)和诊断乳腺癌。

    可采用以下试验和程序:

  • 一般检查:对身体的检查,以检查身体的一般健康情况,包括检查疾病的状况,如肿块或任何其他看起来异常的地方。还将记录患者的健康习惯、既往疾病和治疗史。
  • 临床乳房检查(CBE):由医生或其他健康专家对乳房进行的检查。医生会仔细触摸乳房和腋下是否有肿块或任何异常的东西。
  • B超检查:一种将高能声波(超声波)从内部组织或器官反射并产生回声的过程。这些回声形成了一种称为超声图的人体组织图像。这张照片可以打印出来以后看。
  • 乳房x光片:做乳房X光检查对未出生的婴儿几乎没有危险。即使有癌症,孕妇的乳房X光检查也可能呈阴性。
  • 乳房X光检查。乳房被压在两个平板之间。X光片是用来拍摄乳房组织的。
  • 病理检查:切除细胞或组织以便病理学家在显微镜下观察,以检查是否有癌症的迹象。如果发现乳房肿块,可以做活检。
  • 有三种类型的乳腺活检:

  • 局部切除:切除整个组织块
  • 粗针穿刺:用粗针取出组织。
  • 细针穿刺:用细针取出组织或液体。
  • 如果发现了癌症,就要做检测来研究癌细胞。

    关于最佳治疗的决定是基于这些测试的结果和未出生婴儿的月龄。测试提供以下信息:

  • 癌症的生长速度有多快。
  • 癌症扩散到身体其他部位的可能性有多大。
  • 某些治疗效果如何。
  • 癌症复发的可能性有多大。
  • 测试可能包括以下内容:

  • 激素检测:一项检测癌组织中雌激素和孕激素受体数量的试验。如果有比正常更多的雌激素或孕激素受体,癌症被称为雌激素受体阳性或孕激素受体阳性。这种类型的乳腺癌可能生长得更快。测试结果显示,在婴儿出生后给予阻断雌激素和孕激素的治疗是否可以阻止癌症的生长。
  • FISH检测:一项实验室测试,测量组织样本中有多少HER2/neu基因,以及有多少HER2/neu蛋白。如果有比常人更多的HER2/neu基因或高于正常水平的HER2/neu蛋白,则称为HER2/neu阳性。这种类型的乳腺癌可能生长得更快,更容易扩散到身体的其他部位。在婴儿出生后,可以用靶向HER2/neu蛋白的药物治疗,如曲妥珠单抗和帕妥珠单抗。
  • 多基因测试:对组织样本进行研究以同时观察许多基因活性的测试。这些测试可能有助于预测癌症是否会扩散到身体的其他部位或复发。这个测试有助于预测雌激素受体阳性和淋巴结阴性的一期或二期乳腺癌是否会扩散到身体的其他部位。如果癌症扩散的风险很高,化疗可以降低风险。一项实验室研究,研究了70种不同基因在患有早期浸润性乳腺癌的妇女的乳腺癌组织中的活性,这些乳腺癌没有扩散到淋巴结或扩散到3个或更少的淋巴结。这些基因的活性水平有助于预测乳腺癌是会扩散到身体其他部位还是会复发。如果检测显示癌症扩散或复发的风险很高,可以通过化疗来降低风险。
  • 某些因素影响预后(康复的几率)和治疗选择。

    预后(康复的几率)和治疗方案取决于以下因素:

  • 癌症的分期(肿瘤的大小,以及它是在乳腺中还是已经扩散到身体的其他部位)。
  • 乳腺癌的类型。
  • 未出生婴儿的月龄。
  • 是否有症状或体征。
  • 病人的总体健康状况。
  • Breast Cancer Treatment During Pregnancy (PDQ®)

    General Information About Breast Cancer Treatment During Pregnancy

    Breast cancer is a disease in which malignant (cancer) cells form in the tissues of the breast.

    The breast is made up of lobes and ducts. Each breast has 15 to 20 sections called lobes. Each lobe has many smaller sections called lobules. Lobules end in dozens of tiny bulbs that can make milk. The lobes, lobules, and bulbs are linked by thin tubes called ducts.

    Anatomy of the female breast. The nipple and areola are shown on the outside of the breast. The lymph nodes, lobes, lobules, ducts, and other parts of the inside of the breast are also shown.

    Each breast also has blood vessels and lymph vessels. The lymph vessels carry an almost colorless, watery fluid called lymph. Lymph vessels carry lymph between lymph nodes. Lymph nodes are small, bean-shaped structures found throughout the body. They filter lymph and store white blood cells that help fight infection and disease. Groups of lymph nodes are found near the breast in the axilla (under the arm), above the collarbone, and in the chest.

    Sometimes breast cancer occurs in women who are pregnant or have just given birth.

    Breast cancer occurs about once in every 3,000 pregnancies. It occurs most often in women aged 32 to 38 years. Because many women are choosing to delay having children, it is likely that the number of new cases of breast cancer during pregnancy will increase.

    Signs of breast cancer include a lump or change in the breast.

    These and other signs may be caused by breast cancer or by other conditions. Check with your doctor if you have any of the following:

  • A lump or thickening in or near the breast or in the underarm area.
  • A change in the size or shape of the breast.
  • A dimple or puckering in the skin of the breast.
  • A nipple turned inward into the breast.
  • Fluid, other than breast milk, from the nipple, especially if it's bloody.
  • Scaly, red, or swollen skin on the breast, nipple, or areola (the dark area of skin around the nipple).
  • Dimples in the breast that look like the skin of an orange, called peau d’orange.
  • It may be difficult to detect (find) breast cancer early in pregnant or nursing women.

    The breasts usually get larger, tender, or lumpy in women who are pregnant, nursing, or have just given birth. This occurs because of normal hormone changes that take place during pregnancy. These changes can make small lumps difficult to detect. The breasts may also become denser. It is more difficult to detect breast cancer in women with dense breasts using mammography. Because these breast changes can delay diagnosis, breast cancer is often found at a later stage in these women.

    Breast exams should be part of prenatal and postnatal care.

    To detect breast cancer, pregnant and nursing women should examine their breasts themselves. Women should also receive clinical breast exams during their regular prenatal and postnatal check-ups. Talk to your doctor if you notice any changes in your breasts that you do not expect or that worry you.

    Tests that examine the breasts are used to detect (find) and diagnose breast cancer.

    The following tests and procedures may be used:

  • and : An exam of the body to check general signs of health, including checking for signs of disease, such as lumps or anything else that seems unusual. A history of the patient’s health habits and past illnesses and treatments will also be taken.
  • Clinical breast exam (CBE): An exam of the breast by a doctor or other health professional. The doctor will carefully feel the breasts and under the arms for lumps or anything else that seems unusual.
  • exam: A procedure in which high-energy sound waves (ultrasound) are bounced off internal tissues or organs and make echoes. The echoes form a picture of body tissues called a sonogram. The picture can be printed to look at later.
  • : An x-ray of the breast. A mammogram can be done with little risk to the unborn baby. Mammograms in pregnant women may appear negative even though cancer is present.
  • Mammography. The breast is pressed between two plates. X-rays are used to take pictures of breast tissue.
  • : The removal of cells or tissues so they can be viewed under a microscope by a pathologist to check for signs of cancer. If a lump in the breast is found, a biopsy may be done.
  • There are three types of breast biopsies:

  • : The removal of an entire lump of tissue.
  • : The removal of tissue using a wide needle.
  • : The removal of tissue or fluid, using a thin needle.
  • If cancer is found, tests are done to study the cancer cells.

    Decisions about the best treatment are based on the results of these tests and the age of the unborn baby. The tests give information about:

  • How quickly the cancer may grow.
  • How likely it is that the cancer will spread to other parts of the body.
  • How well certain treatments might work.
  • How likely the cancer is to recur (come back).
  • Tests may include the following:

  • and : A test to measure the amount of estrogen and progesterone (hormones) receptors in cancer tissue. If there are more estrogen or progesterone receptors than normal, the cancer is called estrogen receptor positive or progesterone receptor positive. This type of breast cancer may grow more quickly. The test results show whether treatment to block estrogen and progesterone given after the baby is born may stop the cancer from growing.
  • : A laboratory test to measure how many HER2/neu genes there are and how much HER2/neu protein is made in a sample of tissue. If there are more HER2/neu genes or higher levels of HER2/neu protein than normal, the cancer is called HER2/neu positive. This type of breast cancer may grow more quickly and is more likely to spread to other parts of the body. The cancer may be treated with drugs that target the HER2/neu protein, such as trastuzumab and pertuzumab, after the baby is born.
  • Multigene tests: Tests in which samples of tissue are studied to look at the activity of many genes at the same time. These tests may help predict whether cancer will spread to other parts of the body or recur (come back).: This test helps predict whether stage I or stage II breast cancer that is estrogen receptor positive and node-negative will spread to other parts of the body. If the risk of the cancer spreading is high, chemotherapy may be given to lower the risk.: A laboratory test in which the activity of 70 different genes is looked at in the breast cancer tissue of women who have early-stage invasive breast cancer that has not spread to lymph nodes or has spread to 3 or fewer lymph nodes. The activity level of these genes helps predict whether breast cancer will spread to other parts of the body or come back. If the test shows that the risk that the cancer will spread or come back is high, chemotherapy may be given to lower the risk.
  • Certain factors affect prognosis (chance of recovery) and treatment options.

    The prognosis (chance of recovery) and treatment options depend on the following:

  • The stage of the cancer (the size of the tumor and whether it is in the breast only or has spread to other parts of the body).
  • The type of breast cancer.
  • The age of the unborn baby.
  • Whether there are signs or symptoms.
  • The patient’s general health.
  • 妊娠期乳腺癌治疗(PDQ®)

    乳腺癌的阶段分期

    乳腺癌被诊断出来后,就要进行检测,以确定癌细胞是否已经扩散到乳腺或身体的其他部位。

    查明癌症是否已扩散到乳房内或身体其他部位的过程称为分期。从分期过程中收集的信息来确定疾病的严重程度,依据病情来指导下一步治疗。

    有些治疗方案可能使未出生的婴儿暴露在有害的辐射或染料下。这些方案只有在绝对必要时才执行。可以采取某些措施使未出生的婴儿尽可能少地受到辐射,例如使用铅内衬的防护罩覆盖腹部。

    以下测试和方法可用于在怀孕期间对乳腺癌进行分期:

  • 胸部X光片:胸部器官和骨骼的X光片。x射线是一种能量束,它可以穿过身体并拍成胶片,拍下身体内部区域的照片。
  • 骨扫描:一种检查骨骼中是否存在快速分裂的细胞(例如癌细胞)的方法。极少量的放射性物质被注入静脉并流经血液。放射性物质聚集在患癌症的骨头中,由扫描仪检测。
  • B超检查:一种将高能声波(超声波)从内部组织或器官(如肝脏)反射并产生回声的过程。这些回声形成了一种称为超声图的人体组织图像。这张照片可以打印出来,以便以后再看。
  • (磁共振成像):一种利用磁体、无线电波和计算机对身体内部区域(如大脑)进行一系列详细成像的过程。这个过程也被称为核磁共振成像(NMRI)。
  • 癌症在体内传播有三种方式。

    癌症可以通过组织、淋巴系统和血液传播:

  • 组织。癌症从开始的地方扩散到附近区域。
  • 淋巴系统。癌细胞从它开始的地方通过淋巴系统扩散。癌细胞通过淋巴管到达身体的其他部位。
  • 血液。癌细胞从它开始的地方通过血液扩散。癌症通过血管到达身体的其他部位。
  • 癌症可能从开始的地方扩散到身体的其他部位。

    当癌症扩散到身体的另一部位时,就叫做转移。癌细胞从它们开始的地方(原发性肿瘤)分离,并通过淋巴系统或血液转移。

  • 淋巴系统。癌细胞进入淋巴系统,穿过淋巴管,在身体的另一部分形成肿瘤(转移瘤)。
  • 血液。癌症进入血液,穿过血管,在身体的另一部分形成肿瘤(转移瘤)。
  • 转移性肿瘤与原发性肿瘤是同一类型的肿瘤。例如,如果乳腺癌扩散到骨骼,骨骼中的癌细胞实际上就是乳腺癌细胞。这种疾病是转移性乳腺癌,而不是骨癌。

    许多癌症患者的死亡是由于癌症从最初的肿瘤转移到其他组织和器官而引起的,这叫做转移癌。这个动画展示了癌细胞是如何从最初形成的身体部位转移到身体其他部位的。

    在乳腺癌中,分期取决于原发肿瘤的大小和位置、癌细胞向邻近淋巴结或身体其他部位的扩散、肿瘤分级以及是否存在某些生物标志物。

    为了计划最好的治疗方案和了解你的预后,了解乳腺癌的分期是很重要的。

    乳腺癌分期分为三类:

  • 预后分期首先用于根据病史、体检、影像学检查(如果完成)和活检为所有患者指定一个阶段。临床预后阶段由TNM系统(肿瘤分期系统)、肿瘤分级和生物标志物状态(ER、PR、HER2)来描述。在临床分期中,可用乳腺钼靶X线或超声检查淋巴结是否有癌灶的迹象。
  • 病理预后分期则用于首次接受手术治疗的患者。病理预后分期基于所有临床信息、生物标志物状况以及手术中切除的乳腺组织和淋巴结的实验室检测结果。
  • 分期是根据TNM系统中所描述的肿瘤的大小和扩散情况来定的。在没有生物标志物检测的地区,解剖分期被使用。美国不使用解剖分期。
  • TNM系统用于描述原发性肿瘤的大小以及肿瘤向邻近淋巴结或身体其他部位的扩散情况。

    对于乳腺癌,TNM系统描述肿瘤如下:

    肿瘤(T)。肿瘤的大小和位置。

    肿瘤大小通常以毫米或厘米为单位。可以用mm表示肿瘤大小的常用项目包括:尖铅笔尖(1 mm)、新的蜡笔尖(2 mm)、铅笔式橡皮擦(5 mm)、豌豆(10 mm)、花生(20 mm)和石灰石(50 mm)。
  • TX:无法评估原发性肿瘤。
  • T0:没有乳腺原发性肿瘤的迹象。
  • Tis:原位癌。乳腺原位癌有两种类型:
  • 乳腺导管原位癌(DCIS):DCIS是一种在乳腺导管内壁发生异常细胞的疾病。这些异常细胞没有扩散到乳腺导管外的其他组织。在某些情况下,DCIS可能成为浸润性乳腺癌,并能扩散到其他组织。目前,还没有办法知道哪些病变会成为侵袭性病变。
  • 乳头乳晕湿疹样癌(佩吉特病):乳头乳晕湿疹样癌是一种在乳头皮肤细胞中发现异常细胞并可能扩散到乳晕的疾病。它不是根据TNM系统进行分期的。如果佩吉特病和浸润性乳腺癌存在,TNM系统用于分期浸润性乳腺癌。
  • T1:肿瘤小于等于20毫米。根据肿瘤的大小,T1肿瘤有4种亚型:
  • T1mi:肿瘤小于等于1毫米。
  • T1a:肿瘤大于1毫米但小于等于5毫米。
  • T1b:肿瘤大于5毫米但小于等于10毫米。
  • T1c:肿瘤大于10毫米但小于等于20毫米。
  • T2:肿瘤大于20毫米但小于等于50毫米。
  • T3:肿瘤大于50毫米。
  • T4:肿瘤描述如下:
  • T4a:肿瘤已经长到了胸壁。
  • T4b:肿瘤已长入皮肤,在乳房皮肤表面形成溃疡,与原发肿瘤在同一乳房内形成小肿瘤,和/或乳房皮肤发生肿胀。
  • T4c:肿瘤已经生长到胸壁和皮肤。
  • T4d:炎性乳腺癌的乳腺上三分之一或更多的皮肤是红色和肿胀的(称为橘皮样改变)。
  • 淋巴结(N)。癌细胞扩散的淋巴结的大小和位置。

    当淋巴结被手术切除并在显微镜下被病理学家研究时,病理分期被用来描述淋巴结。淋巴结的病理分期描述如下。

  • NX:无法评估淋巴结。
  • N0:淋巴结中没有癌症的迹象,或淋巴结中不超过0.2毫米的微小癌细胞团。
  • N1:有以下其中一种情况:
  • N1mi:癌细胞扩散到腋窝淋巴结,大于0.2毫米但小于等于2毫米。
  • N1a:癌细胞已经扩散到1到3个腋窝淋巴结,其中至少一个淋巴结的癌细胞大于2毫米。
  • N1b:癌细胞已扩散到与原发肿瘤同侧胸骨附近的淋巴结,癌细胞大于0.2毫米且已经前哨淋巴结活检发现。腋窝淋巴结未发现癌。
  • N1c:癌细胞已经扩散到1到3个腋窝淋巴结,其中至少一个淋巴结的癌细胞大于2毫米。与原发性肿瘤位于同侧胸骨附近的淋巴结在前哨淋巴结活检中也发现癌细胞。
  • N2:癌症被描述为以下之一:
  • N2a:癌细胞已经扩散到4到9个腋窝淋巴结,其中至少一个淋巴结的癌细胞大于2毫米。
  • N2b:癌细胞已经扩散到胸骨附近的淋巴结,通过影像学检查发现癌细胞。前哨淋巴结活检或淋巴结清扫均未发现腋窝淋巴结癌。
  • N3:癌症被描述为以下之一:
  • N3a:癌细胞已经扩散到10个或更多的腋窝淋巴结,其中至少一个淋巴结的癌细胞大于2毫米,或者癌细胞已经扩散到锁骨下淋巴结。
  • N3b:癌细胞已经扩散到1到9个腋窝淋巴结,其中至少一个淋巴结的癌细胞大于2毫米。癌细胞也扩散到胸骨附近的淋巴结,通过影像学检查发现癌细胞;
  • 癌细胞已经扩散到4到9个腋窝淋巴结,其中至少有一个淋巴结大于2毫米。癌细胞也已经扩散到与原发肿瘤同侧胸骨附近的淋巴结,癌细胞大于0.2毫米,且通过前哨淋巴结活检发现。

  • N3c:癌症已经扩散到与原发肿瘤位于同一侧的锁骨上方的淋巴结。
  • 当使用乳腺钼靶或超声进行淋巴结检查时,会产生临床分期。淋巴结的临床分期在这里没有描述。

    转移(M)。癌症扩散到身体其他部位。

  • M0:没有迹象表明癌症已经扩散到身体的其他部位。
  • M1:癌症已经扩散到身体的其他部位,通常是骨骼、肺、肝或大脑。如果癌细胞已经扩散到远处的淋巴结,淋巴结中的癌细胞大于0.2毫米。这种癌症被称为转移性乳腺癌。
  • 分级系统用来描述乳腺肿瘤生长和扩散的速度。

    分级系统根据癌细胞和组织在显微镜下的异常情况以及癌细胞生长和扩散的速度来描述肿瘤。低级癌细胞看起来更像正常细胞,生长和扩散的速度往往比高级癌细胞慢。为了描述癌细胞和组织的异常程度,病理学家将评估以下三个特征:

  • 有多少肿瘤组织中含有正常的乳腺导管。
  • 肿瘤细胞中细胞核的大小和形状。
  • 有多少分裂细胞存在,这是衡量肿瘤细胞生长和分裂的速度。
  • 对于每一个特征,病理学家的评分为1到3分;评分为“1”表示细胞和肿瘤组织看起来最像正常的细胞和组织,评分为“3”表示细胞和组织看起来最不正常。每个特征的分数相加得到的总分在3到9之间。

    可能有三个等级:

  • 总分3-5分:G1(低级别或高分化)。
  • 总分6-7分:G2(中级别或中分化)。
  • 总分8-9分:G3(高级别或低分化)。
  • 生物标记物检测是用来确定乳腺癌细胞是否有某些受体。

    健康的乳腺细胞,和一些乳腺癌细胞,有附着雌激素和孕激素受体(生物标记物)。这些激素是健康细胞和一些乳腺癌细胞生长和分裂所必需的。为了检查这些生物标记物,在活检或手术过程中会取出含有乳腺癌细胞的组织样本。这些样本在实验室进行测试,以确定乳腺癌细胞是否有雌激素或孕激素受体。

    另一种被称为HER2的受体(生物标记物)在所有乳腺癌细胞表面都有发现。HER2受体是乳腺癌细胞生长和分裂所必需的。

    对于乳腺癌,生物标志物检测包括以下内容:

  • 雌激素受体。如果乳腺癌细胞有雌激素受体,癌细胞被称为ER阳性(ER+)。如果乳腺癌细胞没有雌激素受体,癌细胞被称为ER阴性(ER-)。
  • 孕酮受体(PR)。如果乳腺癌细胞有孕酮受体,癌细胞被称为PR阳性(PR+)。如果乳腺癌细胞没有孕酮受体,癌细胞被称为PR阴性(PR-)。
  • 人表皮生长因子2型受体(HER2/neu或HER2)。如果乳腺癌细胞表面的HER2受体数量大于正常值,则称为HER2阳性(HER2+)。如果乳腺癌细胞表面有正常数量的HER2,癌细胞称为HER2阴性(HER2-)。HER2+乳腺癌比HER2-乳腺癌生长和分裂的速度更快。
  • 有时乳腺癌细胞会被描述为三阴性或三阳性。

  • 三阴性。如果乳腺癌细胞雌激素受体阴性,孕激素受体阴性,及HER2受体阴性,癌细胞被称为三阴性。
  • 三阳性。如果乳腺癌细胞确实有雌激素受体、孕激素受体和大于正常量的HER2受体,则癌细胞被称为三阳性。
  • 了解雌激素受体、孕激素受体和HER2受体的状态对选择最佳治疗方案是很重要的。有些药物可以阻止受体与雌激素和孕激素的结合,阻止癌症的生长。其他药物可以用来阻断乳腺癌细胞表面的HER2受体,阻止癌细胞生长。

    将TNM系统、分级系统和生物标志物状态结合起来,可以确定乳腺癌的分期。

    以下是三个结合TNM系统、分级系统和生物标记物状态的例子,以确定第一次治疗是手术的妇女乳腺癌的病理预后阶段:

    如果肿瘤大小为30毫米(T2),没有扩散到附近的淋巴结(N0),没有扩散到身体的远处(M0),并且是:

  • 1级
  • HER2+
  • ER-
  • PR-
  • 癌症是ⅡA期。

    如果肿瘤大小为53毫米(T3),扩散到4到9个腋窝淋巴结(N2),没有扩散到身体的其他部位(M0),并且是:

  • 2级
  • HER2+
  • ER+
  • PR-
  • 肿瘤是 IIIA期。

    如果肿瘤大小为65毫米(T3),扩散到3个腋窝淋巴结(N1a),扩散到肺(M1),并且是:

  • 1级
  • HER2+
  • ER-
  • PR-
  • 癌症是4期(转移性乳腺癌)。

    咨询你的医生,了解你的乳腺癌是什么阶段,以及如何利用它来为你规划最佳治疗方案。

    手术后,你的医生将收到一份病理报告,描述原发肿瘤的大小和位置,癌细胞向附近淋巴结的扩散,肿瘤分级,以及是否存在某些生物标志物。病理报告和其他检测结果用于确定乳腺癌的分期。

    你可能会有很多问题。请你的医生解释分期是如何决定治疗癌症的最佳选择,以及是否有适合你的临床试验。

    Breast Cancer Treatment During Pregnancy (PDQ®)

    Stages of Breast Cancer

    After breast cancer has been diagnosed, tests are done to find out if cancer cells have spread within the breast or to other parts of the body.

    The process used to find out if the cancer has spread within the breast or to other parts of the body is called staging. The information gathered from the staging process determines the stage of the disease. It is important to know the stage in order to plan treatment.

    Some procedures may expose the unborn baby to harmful radiation or dyes. These procedures are done only if absolutely necessary. Certain actions can be taken to expose the unborn baby to as little radiation as possible, such as the use of a lead-lined shield to cover the abdomen.

    The following tests and procedures may be used to stage breast cancer during pregnancy:

  • : An x-ray of the organs and bones inside the chest. An x-ray is a type of energy beam that can go through the body and onto film, making a picture of areas inside the body.
  • : A procedure to check if there are rapidly dividing cells, such as cancer cells, in the bone. A very small amount of radioactive material is injected into a vein and travels through the bloodstream. The radioactive material collects in bones with cancer and is detected by a scanner.
  • exam: A procedure in which high-energy sound waves (ultrasound) are bounced off internal tissues or organs, such as the liver, and make echoes. The echoes form a picture of body tissues called a sonogram. The picture can be printed to be looked at later.
  • (magnetic resonance imaging): A procedure that uses a magnet, radio waves, and a computer to make a series of detailed pictures of areas inside the body, such as the brain. This procedure is also called nuclear magnetic resonance imaging (NMRI).
  • There are three ways that cancer spreads in the body.

    Cancer can spread through tissue, the lymph system, and the blood:

  • Tissue. The cancer spreads from where it began by growing into nearby areas.
  • Lymph system. The cancer spreads from where it began by getting into the lymph system. The cancer travels through the lymph vessels to other parts of the body.
  • Blood. The cancer spreads from where it began by getting into the blood. The cancer travels through the blood vessels to other parts of the body.
  • Cancer may spread from where it began to other parts of the body.

    When cancer spreads to another part of the body, it is called metastasis. Cancer cells break away from where they began (the primary tumor) and travel through the lymph system or blood.

  • Lymph system. The cancer gets into the lymph system, travels through the lymph vessels, and forms a tumor (metastatic tumor) in another part of the body.
  • Blood. The cancer gets into the blood, travels through the blood vessels, and forms a tumor (metastatic tumor) in another part of the body.
  • The metastatic tumor is the same type of cancer as the primary tumor. For example, if breast cancer spreads to the bone, the cancer cells in the bone are actually breast cancer cells. The disease is metastatic breast cancer, not bone cancer.

    Many cancer deaths are caused when cancer moves from the original tumor and spreads to other tissues and organs. This is called metastatic cancer. This animation shows how cancer cells travel from the place in the body where they first formed to other parts of the body.

    In breast cancer, stage is based on the size and location of the primary tumor, the spread of cancer to nearby lymph nodes or other parts of the body, tumor grade, and whether certain biomarkers are present.

    To plan the best treatment and understand your prognosis, it is important to know the breast cancer stage.

    There are 3 types of breast cancer stage groups:

  • Prognostic Stage is used first to assign a stage for all patients based on health history, physical exam, imaging tests (if done), and biopsies. The Clinical Prognostic Stage is described by the TNM system, tumor grade, and biomarker status (ER, PR, HER2). In clinical staging, mammography or ultrasound is used to check the lymph nodes for signs of cancer.
  • Pathological Prognostic Stage is then used for patients who have surgery as their first treatment. The Pathological Prognostic Stage is based on all clinical information, biomarker status, and laboratory test results from breast tissue and lymph nodes removed during surgery.
  • Stage is based on the size and the spread of cancer as described by the TNM system. The Anatomic Stage is used in parts of the world where biomarker testing is not available. It is not used in the United States.
  • The TNM system is used to describe the size of the primary tumor and the spread of cancer to nearby lymph nodes or other parts of the body.

    For breast cancer, the TNM system describes the tumor as follows:

    Tumor (T). The size and location of the tumor.

    Tumor sizes are often measured in millimeters (mm) or centimeters. Common items that can be used to show tumor size in mm include: a sharp pencil point (1 mm), a new crayon point (2 mm), a pencil-top eraser (5 mm), a pea (10 mm), a peanut (20 mm), and a lime (50 mm).
  • TX: Primary tumor cannot be assessed.
  • T0: No sign of a primary tumor in the breast.
  • Tis: Carcinoma in situ. There are 2 types of breast carcinoma in situ:
  • Tis (DCIS): DCIS is a condition in which abnormal cells are found in the lining of a breast duct. The abnormal cells have not spread outside the duct to other tissues in the breast. In some cases, DCIS may become invasive breast cancer that is able to spread to other tissues. At this time, there is no way to know which lesions can become invasive.
  • Tis (Paget disease): Paget disease of the nipple is a condition in which abnormal cells are found in the skin cells of the nipple and may spread to the areola. It is not staged according to the TNM system. If Paget disease AND an invasive breast cancer are present, the TNM system is used to stage the invasive breast cancer.
  • T1: The tumor is 20 millimeters or smaller. There are 4 subtypes of a T1 tumor depending on the size of the tumor:
  • T1mi: the tumor is 1 millimeter or smaller.
  • T1a: the tumor is larger than 1 millimeter but not larger than 5 millimeters.
  • T1b: the tumor is larger than 5 millimeters but not larger than 10 millimeters.
  • T1c: the tumor is larger than 10 millimeters but not larger than 20 millimeters.
  • T2: The tumor is larger than 20 millimeters but not larger than 50 millimeters.
  • T3: The tumor is larger than 50 millimeters.
  • T4: The tumor is described as one of the following:
  • T4a: the tumor has grown into the chest wall.
  • T4b: the tumor has grown into the skin—an ulcer has formed on the surface of the skin on the breast, small tumor nodules have formed in the same breast as the primary tumor, and/or there is swelling of the skin on the breast.
  • T4c: the tumor has grown into the chest wall and the skin.
  • T4d: inflammatory breast cancer—one-third or more of the skin on the breast is red and swollen (called peau d’orange).
  • Lymph Node (N). The size and location of lymph nodes where cancer has spread.

    When the lymph nodes are removed by surgery and studied under a microscope by a pathologist, pathologic staging is used to describe the lymph nodes. The pathologic staging of lymph nodes is described below.

  • NX: The lymph nodes cannot be assessed.
  • N0: No sign of cancer in the lymph nodes, or tiny clusters of cancer cells not larger than 0.2 millimeters in the lymph nodes.
  • N1: Cancer is described as one of the following:
  • N1mi: cancer has spread to the axillary (armpit area) lymph nodes and is larger than 0.2 millimeters but not larger than 2 millimeters.
  • N1a: cancer has spread to 1 to 3 axillary lymph nodes and the cancer in at least one of the lymph nodes is larger than 2 millimeters.
  • N1b: cancer has spread to lymph nodes near the breastbone on the same side of the body as the primary tumor, and the cancer is larger than 0.2 millimeters and is found by sentinel lymph node biopsy. Cancer is not found in the axillary lymph nodes.
  • N1c: cancer has spread to 1 to 3 axillary lymph nodes and the cancer in at least one of the lymph nodes is larger than 2 millimeters. Cancer is also found by sentinel lymph node biopsy in the lymph nodes near the breastbone on the same side of the body as the primary tumor.
  • N2: Cancer is described as one of the following:
  • N2a: cancer has spread to 4 to 9 axillary lymph nodes and the cancer in at least one of the lymph nodes is larger than 2 millimeters.
  • N2b: cancer has spread to lymph nodes near the breastbone and the cancer is found by imaging tests. Cancer is not found in the axillary lymph nodes by sentinel lymph node biopsy or lymph node dissection.
  • N3: Cancer is described as one of the following:
  • N3a: cancer has spread to 10 or more axillary lymph nodes and the cancer in at least one of the lymph nodes is larger than 2 millimeters, or cancer has spread to lymph nodes below the collarbone.
  • N3b: cancer has spread to 1 to 9 axillary lymph nodes and the cancer in at least one of the lymph nodes is larger than 2 millimeters. Cancer has also spread to lymph nodes near the breastbone and the cancer is found by imaging tests;
  • or

    cancer has spread to 4 to 9 axillary lymph nodes and cancer in at least one of the lymph nodes is larger than 2 millimeters. Cancer has also spread to lymph nodes near the breastbone on the same side of the body as the primary tumor, and the cancer is larger than 0.2 millimeters and is found by sentinel lymph node biopsy.

  • N3c: cancer has spread to lymph nodes above the collarbone on the same side of the body as the primary tumor.
  • When the lymph nodes are checked using mammography or ultrasound, it is called clinical staging. The clinical staging of lymph nodes is not described here.

    Metastasis (M). The spread of cancer to other parts of the body.

  • M0: There is no sign that cancer has spread to other parts of the body.
  • M1: Cancer has spread to other parts of the body, most often the bones, lungs, liver, or brain. If cancer has spread to distant lymph nodes, the cancer in the lymph nodes is larger than 0.2 millimeters. The cancer is called metastatic breast cancer.
  • The grading system is used to describe how quickly a breast tumor is likely to grow and spread.

    The grading system describes a tumor based on how abnormal the cancer cells and tissue look under a microscope and how quickly the cancer cells are likely to grow and spread. Low-grade cancer cells look more like normal cells and tend to grow and spread more slowly than high-grade cancer cells. To describe how abnormal the cancer cells and tissue are, the pathologist will assess the following three features:

  • How much of the tumor tissue has normal breast ducts.
  • The size and shape of the nuclei in the tumor cells.
  • How many dividing cells are present, which is a measure of how fast the tumor cells are growing and dividing.
  • For each feature, the pathologist assigns a score of 1 to 3; a score of “1” means the cells and tumor tissue look the most like normal cells and tissue, and a score of “3” means the cells and tissue look the most abnormal. The scores for each feature are added together to get a total score between 3 and 9.

    Three grades are possible:

  • Total score of 3 to 5: G1 (Low grade or well differentiated).
  • Total score of 6 to 7: G2 (Intermediate grade or moderately differentiated).
  • Total score of 8 to 9: G3 (High grade or poorly differentiated).
  • Biomarker testing is used to find out whether breast cancer cells have certain receptors.

    Healthy breast cells, and some breast cancer cells, have receptors (biomarkers) that attach to the hormones estrogen and progesterone. These hormones are needed for healthy cells, and some breast cancer cells, to grow and divide. To check for these biomarkers, samples of tissue containing breast cancer cells are removed during a biopsy or surgery. The samples are tested in a laboratory to see whether the breast cancer cells have estrogen or progesterone receptors.

    Another type of receptor (biomarker) that is found on the surface of all breast cancer cells is called HER2. HER2 receptors are needed for the breast cancer cells to grow and divide.

    For breast cancer, biomarker testing includes the following:

  • Estrogen receptor (ER). If the breast cancer cells have estrogen receptors, the cancer cells are called ER positive (ER+). If the breast cancer cells do not have estrogen receptors, the cancer cells are called ER negative (ER-).
  • Progesterone receptor (PR). If the breast cancer cells have progesterone receptors, the cancer cells are called PR positive (PR+). If the breast cancer cells do not have progesterone receptors, the cancer cells are called PR negative (PR-).
  • Human epidermal growth factor type 2 receptor (HER2/neu or HER2). If the breast cancer cells have larger than normal amounts of HER2 receptors on their surface, the cancer cells are called HER2 positive (HER2+). If the breast cancer cells have a normal amount of HER2 on their surface, the cancer cells are called HER2 negative (HER2-). HER2+ breast cancer is more likely to grow and divide faster than HER2- breast cancer.
  • Sometimes the breast cancer cells will be described as triple negative or triple positive.

  • Triple negative. If the breast cancer cells do not have estrogen receptors, progesterone receptors, or a larger than normal amount of HER2 receptors, the cancer cells are called triple negative.
  • Triple positive. If the breast cancer cells do have estrogen receptors, progesterone receptors, and a larger than normal amount of HER2 receptors, the cancer cells are called triple positive.
  • It is important to know the estrogen receptor, progesterone receptor, and HER2 receptor status to choose the best treatment. There are drugs that can stop the receptors from attaching to the hormones estrogen and progesterone and stop the cancer from growing. Other drugs may be used to block the HER2 receptors on the surface of the breast cancer cells and stop the cancer from growing.

    The TNM system, the grading system, and biomarker status are combined to find out the breast cancer stage.

    Here are 3 examples that combine the TNM system, the grading system, and the biomarker status to find out the Pathological Prognostic breast cancer stage for a woman whose first treatment was surgery:

    If the tumor size is 30 millimeters (T2), has not spread to nearby lymph nodes (N0), has not spread to distant parts of the body (M0), and is:

  • Grade 1
  • HER2+
  • ER-
  • PR-
  • The cancer is stage IIA.

    If the tumor size is 53 millimeters (T3), has spread to 4 to 9 axillary lymph nodes (N2), has not spread to other parts of the body (M0), and is:

  • Grade 2
  • HER2+
  • ER+
  • PR-
  • The tumor is stage IIIA.

    If the tumor size is 65 millimeters (T3), has spread to 3 axillary lymph nodes (N1a), has spread to the lungs (M1), and is:

  • Grade 1
  • HER2+
  • ER-
  • PR-
  • The cancer is stage IV (metastatic breast cancer).

    Talk to your doctor to find out what your breast cancer stage is and how it is used to plan the best treatment for you.

    After surgery, your doctor will receive a pathology report that describes the size and location of the primary tumor, the spread of cancer to nearby lymph nodes, tumor grade, and whether certain biomarkers are present. The pathology report and other test results are used to determine your breast cancer stage.

    You are likely to have many questions. Ask your doctor to explain how staging is used to decide the best options to treat your cancer and whether there are clinical trials that might be right for you.

    妊娠期乳腺癌治疗(PDQ®)

    治疗方案概述

    孕妇的治疗取决于疾病的阶段和胎儿的月龄。

    使用三种标准治疗:

    手术

    大多数患有乳腺癌的孕妇都要做切除乳房的手术。手臂下方的一些淋巴结可以切除,这样病理学家就可以在显微镜下确定是否有癌细胞。

    癌症切除的手术类型包括:

  • 改良根治术:手术切除包括整个乳腺、腋下淋巴结、胸肌筋膜,有时还包括部分胸壁肌肉。这种手术在孕妇中最常见。
  • 改良根治术。虚线显示了整个乳房和一些淋巴结被切除的地方。部分胸壁肌肉也可能切除。
  • 保乳手术:切除癌细胞及其周围正常组织的手术,但不能切除乳腺本身。如果癌细胞靠近胸壁,部分胸壁组织也可能被切除。这种类型的手术也可以称为肿块切除术、乳腺部分切除术、乳腺节段切除术、象限切除术或保乳手术。
  • 保乳手术。肿瘤和周围的一些正常组织被切除,但乳房本身却没有。近腋窝处的一些淋巴结可能切除。如果癌细胞靠近胸壁,部分胸壁组织也可能被切除。

    在医生切除了手术时能看到的所有癌细胞后,一些患者可能会在手术后接受化疗或放疗,以杀死任何残留的癌细胞。对于早期乳腺癌孕妇,在婴儿出生后给予放射治疗和激素治疗。术后给予的治疗,是为了降低癌症复发的风险,称为辅助治疗。

    放射治疗

    放射治疗是一种利用高能x射线或其他类型的辐射杀死或阻止癌细胞生长的癌症治疗方法。放射治疗有两种类型:

  • 外部放射治疗使用体外的一台机器向癌细胞发送辐射。
  • 内部放射治疗使用一种密封在针头、种子、电线或导管中的放射性物质,这些针头、种子、电线或导管直接放在癌症中或癌旁。
  • 放射治疗的方式取决于所治疗癌症的类型和分期。

    婴儿出生后,早期(I期或II期)乳腺癌孕妇可接受外照射治疗。晚期(III期或IV期)乳腺癌患者可在妊娠头3个月后接受外照射治疗,如有可能,可延迟至婴儿出生后接受外照射治疗。

    化疗

    化疗是一种用药物来阻止癌细胞生长的癌症治疗方法,既可以杀死癌细胞,也可以阻止癌细胞分裂。当化疗通过口服或注射到静脉或肌肉中时,药物进入血液并能到达全身的癌细胞(全身化疗)。当化疗直接进入脑脊液、器官或腹腔等体腔时,药物主要影响这些区域的癌细胞(区域化疗)。

    化疗的方式取决于所治疗癌症的类型和分期。妊娠期乳腺癌采用全身化疗。

    在怀孕的前3个月通常不进行化疗。在这段时间后进行化疗通常不会对胎儿造成伤害,但可能会导致早产或低出生体重。

    有关更多信息,请参阅批准用于乳腺癌的药物。

    结束妊娠似乎并不能提高母亲的生存机会。

    因为终止妊娠不太可能提高母亲的存活率,所以通常不是一种治疗选择。

    乳腺癌的治疗可能会引起副作用。

    有关癌症治疗引起的副作用的信息,请参阅我们的副作用页面。

    Breast Cancer Treatment During Pregnancy (PDQ®)

    Treatment Option Overview

    Treatment options for pregnant women depend on the stage of the disease and the age of the unborn baby.

    Three types of standard treatment are used:

    Surgery

    Most pregnant women with breast cancer have surgery to remove the breast. Some of the lymph nodes under the arm may be removed so they can be checked under a microscope by a pathologist for signs of cancer.

    Types of surgery to remove the cancer include:

  • Modified radical mastectomy: Surgery to remove the whole breast that has cancer, many of the lymph nodes under the arm, the lining over the chest muscles, and sometimes, part of the chest wall muscles. This type of surgery is most common in pregnant women.
  • Modified radical mastectomy. The dotted line shows where the entire breast and some lymph nodes are removed. Part of the chest wall muscle may also be removed.
  • Breast-conserving surgery: Surgery to remove the cancer and some normal tissue around it, but not the breast itself. Part of the chest wall lining may also be removed if the cancer is near it. This type of surgery may also be called lumpectomy, partial mastectomy, segmental mastectomy, quadrantectomy, or breast-sparing surgery.
  • Breast-conserving surgery. The tumor and some normal tissue around it are removed, but not the breast itself. Some lymph nodes under the arm may be removed. Part of the chest wall lining may also be removed if the cancer is near it.

    After the doctor removes all of the cancer that can be seen at the time of surgery, some patients may be given chemotherapy or radiation therapy after surgery to kill any cancer cells that are left. For pregnant women with early-stage breast cancer, radiation therapy and hormone therapy are given after the baby is born. Treatment given after surgery, to lower the risk that the cancer will come back, is called adjuvant therapy.

    Radiation therapy

    Radiation therapy is a cancer treatment that uses high-energy x-rays or other types of radiation to kill cancer cells or keep them from growing. There are two types of radiation therapy:

  • External radiation therapy uses a machine outside the body to send radiation toward the cancer.
  • Internal radiation therapy uses a radioactive substance sealed in needles, seeds, wires, or catheters that are placed directly into or near the cancer.
  • The way the radiation therapy is given depends on the type and stage of the cancer being treated.

    External radiation therapy may be given to pregnant women with early stage (stage I or II) breast cancer after the baby is born. Women with late stage (stage III or IV) breast cancer may be given external radiation therapy after the first 3 months of pregnancy or, if possible, radiation therapy is delayed until after the baby is born.

    Chemotherapy

    Chemotherapy is a cancer treatment that uses drugs to stop the growth of cancer cells, either by killing the cells or by stopping the cells from dividing. When chemotherapy is taken by mouth or injected into a vein or muscle, the drugs enter the bloodstream and can reach cancer cells throughout the body (systemic chemotherapy). When chemotherapy is placed directly into the cerebrospinal fluid, an organ, or a body cavity such as the abdomen, the drugs mainly affect cancer cells in those areas (regional chemotherapy).

    The way the chemotherapy is given depends on the type and stage of the cancer being treated. Systemic chemotherapy is used to treat breast cancer during pregnancy.

    Chemotherapy is usually not given during the first 3 months of pregnancy. Chemotherapy given after this time does not usually harm the unborn baby but may cause early labor or low birth weight.

    See Drugs Approved for Breast Cancer for more information.

    Ending the pregnancy does not seem to improve the mother’s chance of survival.

    Because ending the pregnancy is not likely to improve the mother’s chance of survival, it is not usually a treatment option.

    Treatment for breast cancer may cause side effects.

    For information about side effects caused by treatment for cancer, see our Side Effects page.

    妊娠期乳腺癌治疗(PDQ®)

    妊娠期乳腺癌的治疗选择

    有关下面列出的治疗的信息,请参阅“治疗选项概述”部分。

    早期乳腺癌

    早期乳腺癌孕妇(一期和二期)的治疗方法通常与未怀孕的患者相同,有些变化是为了保护未出生的婴儿。治疗可包括以下内容:

  • 改良根治术,如果乳腺癌在怀孕早期被诊断。
  • 保乳手术,如果乳腺癌在怀孕后期被诊断。婴儿出生后可以进行放射治疗。
  • 改良根治术或妊娠期保乳手术。怀孕3个月后,可以在手术前或手术后进行某些类型的化疗。
  • 妊娠期间不应使用激素治疗和曲妥珠单抗。

    晚期乳腺癌

    妊娠晚期乳腺癌(三期或四期)患者没有标准的治疗方法。治疗可包括以下内容:

  • 放射治疗。
  • 化疗。
  • 妊娠头3个月内不应进行放射治疗和化疗。

    Breast Cancer Treatment During Pregnancy (PDQ®)

    Treatment Options For Breast Cancer During Pregnancy

    For information about the treatments listed below, see the Treatment Option Overview section.

    Early Stage Breast Cancer

    Pregnant women with early-stage breast cancer (stage I and stage II) are usually treated in the same way as patients who are not pregnant, with some changes to protect the unborn baby. Treatment may include the following:

  • Modified radical mastectomy, if the breast cancer was diagnosed early in pregnancy.
  • Breast-conserving surgery, if the breast cancer is diagnosed later in pregnancy. Radiation therapy may be given after the baby is born.
  • Modified radical mastectomy or breast-conserving surgery during pregnancy. After the first 3 months of pregnancy, certain types of chemotherapy may be given before or after surgery.
  • Hormone therapy and trastuzumab should not be given during pregnancy.

    Late-Stage Breast Cancer

    There is no standard treatment for patients with late-stage breast cancer (stage III or stage IV) during pregnancy. Treatment may include the following:

  • Radiation therapy.
  • Chemotherapy.
  • Radiation therapy and chemotherapy should not be given during the first 3 months of pregnancy.

    妊娠期乳腺癌治疗(PDQ®)

    妊娠期乳腺癌特有的问题

    如果计划手术或化疗,应停止哺乳(母乳生产)和母乳喂养。

    如果计划进行手术,应该停止母乳喂养,以减少乳房内的血流量,使其变小。许多化疗药物,特别是环磷酰胺和甲氨蝶呤,可能在母乳中大量出现,并可能对哺乳期婴儿造成伤害。接受化疗的妇女不应母乳喂养。

    停止哺乳并不能改善母亲的预后。

    乳腺癌似乎不会伤害未出生的婴儿。

    乳腺癌细胞似乎不会从母亲传给未出生的婴儿。

    怀孕似乎并不影响过去患过乳腺癌的妇女的生存。

    对于患有乳腺癌的女性来说,怀孕似乎并不影响她们的生存。不过,一些医生建议,女性在接受乳腺癌治疗2年后再尝试生育,这样就能发现癌症的任何早期复发。这可能会影响妇女怀孕的决定。如果母亲患了乳腺癌,胎儿似乎不会受到影响。

    Breast Cancer Treatment During Pregnancy (PDQ®)

    Special Issues About Breast Cancer During Pregnancy

    Lactation (breast milk production) and breast-feeding should be stopped if surgery or chemotherapy is planned.

    If surgery is planned, breast-feeding should be stopped to reduce blood flow in the breasts and make them smaller. Many chemotherapy drugs, especially cyclophosphamide and methotrexate, may occur in high levels in breast milk and may harm the nursing baby. Women receiving chemotherapy should not breast-feed.

    Stopping lactation does not improve the mother's prognosis.

    Breast cancer does not appear to harm the unborn baby.

    Breast cancer cells do not seem to pass from the mother to the unborn baby.

    Pregnancy does not seem to affect the survival of women who have had breast cancer in the past.

    For women who have had breast cancer, pregnancy does not seem to affect their survival. However, some doctors recommend that a woman wait 2 years after treatment for breast cancer before trying to have a baby, so that any early return of the cancer would be detected. This may affect a woman’s decision to become pregnant. The unborn baby does not seem to be affected if the mother has had breast cancer.

    妊娠期乳腺癌治疗(PDQ®)

    了解更多有关怀孕期间乳腺癌的信息

    有关妊娠期乳腺癌的更多信息,请参见以下内容:

  • 乳腺癌主页
  • 乳腺癌预防
  • 乳腺癌筛查
  • DCIS或乳腺癌患者的手术选择
  • 致密乳房:常见问题的答案
  • 批准用于乳腺癌的药物
  • 关于国家癌症研究所的一般癌症信息和其他资源,请参见以下内容:

  • 关于癌症
  • 阶段分期
  • 化疗与你:支持癌症患者
  • 放射治疗与你:支持癌症患者
  • 应对癌症
  • 咨询医生关于癌症的问题
  • 幸存者和护理人员
  • Breast Cancer Treatment During Pregnancy (PDQ®)

    To Learn More About Breast Cancer During Pregnancy

    For more information from the National Cancer Institute about breast cancer during pregnancy, see the following:

  • Breast Cancer Home Page
  • Breast Cancer Prevention
  • Breast Cancer Screening
  • Surgery Choices for Women with DCIS or Breast Cancer
  • Dense Breasts: Answers to Commonly Asked Questions
  • Drugs Approved for Breast Cancer
  • For general cancer information and other resources from the National Cancer Institute, see the following:

  • About Cancer
  • Staging
  • Chemotherapy and You: Support for People With Cancer
  • Radiation Therapy and You: Support for People With Cancer
  • Coping with Cancer
  • Questions to Ask Your Doctor about Cancer
  • For Survivors and Caregivers
  • 妊娠期乳腺癌治疗(PDQ®)

    About This PDQ Summary

    About PDQ

    Physician Data Query (PDQ) is the National Cancer Institute's (NCI's) comprehensive cancer information database. The PDQ database contains summaries of the latest published information on cancer prevention, detection, genetics, treatment, supportive care, and complementary and alternative medicine. Most summaries come in two versions. The health professional versions have detailed information written in technical language. The patient versions are written in easy-to-understand, nontechnical language. Both versions have cancer information that is accurate and up to date and most versions are also available in Spanish.

    PDQ is a service of the NCI. The NCI is part of the National Institutes of Health (NIH). NIH is the federal government’s center of biomedical research. The PDQ summaries are based on an independent review of the medical literature. They are not policy statements of the NCI or the NIH.

    Purpose of This Summary

    This PDQ cancer information summary has current information about the treatment of breast cancer during pregnancy. It is meant to inform and help patients, families, and caregivers. It does not give formal guidelines or recommendations for making decisions about health care.

    Reviewers and Updates

    Editorial Boards write the PDQ cancer information summaries and keep them up to date. These Boards are made up of experts in cancer treatment and other specialties related to cancer. The summaries are reviewed regularly and changes are made when there is new information. The date on each summary ("Updated") is the date of the most recent change.

    The information in this patient summary was taken from the health professional version, which is reviewed regularly and updated as needed, by the PDQ Adult Treatment Editorial Board.

    Clinical Trial Information

    A clinical trial is a study to answer a scientific question, such as whether one treatment is better than another. Trials are based on past studies and what has been learned in the laboratory. Each trial answers certain scientific questions in order to find new and better ways to help cancer patients. During treatment clinical trials, information is collected about the effects of a new treatment and how well it works. If a clinical trial shows that a new treatment is better than one currently being used, the new treatment may become "standard." Patients may want to think about taking part in a clinical trial. Some clinical trials are open only to patients who have not started treatment.

    Clinical trials can be found online at NCI's website. For more information, call the Cancer Information Service (CIS), NCI's contact center, at 1-800-4-CANCER (1-800-422-6237).

    Permission to Use This Summary

    PDQ is a registered trademark. The content of PDQ documents can be used freely as text. It cannot be identified as an NCI PDQ cancer information summary unless the whole summary is shown and it is updated regularly. However, a user would be allowed to write a sentence such as “NCI’s PDQ cancer information summary about breast cancer prevention states the risks in the following way: [include excerpt from the summary].”

    The best way to cite this PDQ summary is:

    PDQ® Adult Treatment Editorial Board. PDQ Breast Cancer Treatment During Pregnancy. Bethesda, MD: National Cancer Institute. Updated . Available at: https://www.cancer.gov/types/breast/patient/pregnancy-breast-treatment-pdq. Accessed . [PMID: 26389161]

    Images in this summary are used with permission of the author(s), artist, and/or publisher for use in the PDQ summaries only. If you want to use an image from a PDQ summary and you are not using the whole summary, you must get permission from the owner. It cannot be given by the National Cancer Institute. Information about using the images in this summary, along with many other images related to cancer can be found in Visuals Online. Visuals Online is a collection of more than 3,000 scientific images.

    Disclaimer

    The information in these summaries should not be used to make decisions about insurance reimbursement. More information on insurance coverage is available on Cancer.gov on the Managing Cancer Care page.

    Contact Us

    More information about contacting us or receiving help with the Cancer.gov website can be found on our Contact Us for Help page. Questions can also be submitted to Cancer.gov through the website’s E-mail Us.

    Breast Cancer Treatment During Pregnancy (PDQ®)

    About This PDQ Summary

    About PDQ

    Physician Data Query (PDQ) is the National Cancer Institute's (NCI's) comprehensive cancer information database. The PDQ database contains summaries of the latest published information on cancer prevention, detection, genetics, treatment, supportive care, and complementary and alternative medicine. Most summaries come in two versions. The health professional versions have detailed information written in technical language. The patient versions are written in easy-to-understand, nontechnical language. Both versions have cancer information that is accurate and up to date and most versions are also available in Spanish.

    PDQ is a service of the NCI. The NCI is part of the National Institutes of Health (NIH). NIH is the federal government’s center of biomedical research. The PDQ summaries are based on an independent review of the medical literature. They are not policy statements of the NCI or the NIH.

    Purpose of This Summary

    This PDQ cancer information summary has current information about the treatment of breast cancer during pregnancy. It is meant to inform and help patients, families, and caregivers. It does not give formal guidelines or recommendations for making decisions about health care.

    Reviewers and Updates

    Editorial Boards write the PDQ cancer information summaries and keep them up to date. These Boards are made up of experts in cancer treatment and other specialties related to cancer. The summaries are reviewed regularly and changes are made when there is new information. The date on each summary ("Updated") is the date of the most recent change.

    The information in this patient summary was taken from the health professional version, which is reviewed regularly and updated as needed, by the PDQ Adult Treatment Editorial Board.

    Clinical Trial Information

    A clinical trial is a study to answer a scientific question, such as whether one treatment is better than another. Trials are based on past studies and what has been learned in the laboratory. Each trial answers certain scientific questions in order to find new and better ways to help cancer patients. During treatment clinical trials, information is collected about the effects of a new treatment and how well it works. If a clinical trial shows that a new treatment is better than one currently being used, the new treatment may become "standard." Patients may want to think about taking part in a clinical trial. Some clinical trials are open only to patients who have not started treatment.

    Clinical trials can be found online at NCI's website. For more information, call the Cancer Information Service (CIS), NCI's contact center, at 1-800-4-CANCER (1-800-422-6237).

    Permission to Use This Summary

    PDQ is a registered trademark. The content of PDQ documents can be used freely as text. It cannot be identified as an NCI PDQ cancer information summary unless the whole summary is shown and it is updated regularly. However, a user would be allowed to write a sentence such as “NCI’s PDQ cancer information summary about breast cancer prevention states the risks in the following way: [include excerpt from the summary].”

    The best way to cite this PDQ summary is:

    PDQ® Adult Treatment Editorial Board. PDQ Breast Cancer Treatment During Pregnancy. Bethesda, MD: National Cancer Institute. Updated . Available at: https://www.cancer.gov/types/breast/patient/pregnancy-breast-treatment-pdq. Accessed . [PMID: 26389161]

    Images in this summary are used with permission of the author(s), artist, and/or publisher for use in the PDQ summaries only. If you want to use an image from a PDQ summary and you are not using the whole summary, you must get permission from the owner. It cannot be given by the National Cancer Institute. Information about using the images in this summary, along with many other images related to cancer can be found in Visuals Online. Visuals Online is a collection of more than 3,000 scientific images.

    Disclaimer

    The information in these summaries should not be used to make decisions about insurance reimbursement. More information on insurance coverage is available on Cancer.gov on the Managing Cancer Care page.

    Contact Us

    More information about contacting us or receiving help with the Cancer.gov website can be found on our Contact Us for Help page. Questions can also be submitted to Cancer.gov through the website’s E-mail Us.

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    目录
    章 节
    妊娠期乳腺癌治疗概况 乳腺癌的阶段分期 治疗方案概述 妊娠期乳腺癌的治疗选择 妊娠期乳腺癌特有的问题 了解更多有关怀孕期间乳腺癌的信息 About This PDQ Summary