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小细胞肺癌的治疗(PDQ®)

关于小细胞肺癌的基本信息

小细胞肺癌是指在肺组织中形成了恶性(癌)细胞的疾病。

肺是位于胸腔内的一对圆锥形的呼吸器官。当你吸气时,肺将氧气带入体内。当你呼气时,肺会释放二氧化碳,这是一种由人体细胞产生的废料。每侧肺都由肺叶组成。左肺有两个肺叶。右肺比左肺稍微大些,有三个肺叶。两条被称作支气管的导管,从气管开始延伸至左肺和右肺。肺癌有时会累及支气管。肺的内部由名为肺泡的微小气囊和名为细支气管的小管组成。

呼吸系统的解剖图,显示了气管、两肺及其肺叶和气道,也显示出淋巴结和横膈。氧气被吸入肺部,通过肺泡的薄膜进入血液(见插图)。

有两种类型的肺癌:小细胞肺癌及非小细胞肺癌。

这份摘要是关于小细胞肺癌及其疗法的。获取更多关于肺癌的信息,请参阅以下PDQ摘要。

  • 非小细胞肺癌的治疗
  • 儿童罕见癌症的治疗
  • 肺癌预防
  • 肺癌筛查
  • 小细胞肺癌主要有两种类型。

    这两种类型包括许多不同种类的细胞。每种类型的癌症细胞以不同的方式生长扩散。小细胞肺癌类型的命名是以在癌症中发现的细胞种类以及这些细胞在显微镜下所观察到的形态为依据的:

  • 小细胞癌(燕麦细胞癌)。
  • 复合性小细胞癌。
  • 吸烟是小细胞肺癌的主要风险因素

    任何增加患病几率的因素都被称为危险因素。有危险因素并不意味着你会得癌症;没有危险因素并不意味着你不会得癌症。如果你认为自己有患肺癌的风险,请咨询你的医生。

    肺癌的风险因素包括以下几种:

  • 过去或现在有抽香烟、烟斗、或雪茄史。这是肺癌最重要的危险因素。一个人开始吸烟的时间越早,吸烟的频率越高,吸烟的时间越长,患肺癌的风险就越大。
  • 二手烟暴露
  • 在工作场所接触石棉、砷、铬、铍、镍、煤烟或焦油。
  • 暴露于下列任何一种辐射:
  • 乳房或胸部的放射治疗。
  • 家中或工作场所的氡。
  • 影像学检查,如CT扫描。
  • 原子弹辐射。
  • 生活在大气污染的环境中
  • 拥有肺癌的家族史。
  • 感染人体免疫缺陷病毒(HIV)。
  • 摄入β-胡萝卜素补充剂和大量吸烟
  • 年龄大是大多数癌症的主要危险因素。随着年龄的增长,患癌症的几率会增加。

    当吸烟和其他风险因素同时存在时,患肺癌的风险增加。

    小细胞肺癌的症状以及体征包括咳嗽,呼吸短促,胸部疼痛。

    这些或其他的症状和体征有可能是由小细胞肺癌或者是其他疾病引起的。如果您有以下情况,请咨询您的医生:

  • 胸部不适或疼痛。
  • 持续存在或随时间而加重的咳嗽
  • 呼吸困难。
  • 喘息。
  • 痰(从肺部咳出的粘液)中带血。
  • 声音嘶哑。
  • 吞咽困难。
  • 食欲不振。
  • 不明原因导致的体重下降。
  • 体外放射治疗是利用体外的机器将辐射发送到癌症部位。
  • 面部和/或颈部静脉肿胀。
  • 用于检测(发现)、诊断小细胞肺癌以及对小细胞肺癌进行分期的肺部检查方法。

    可能采用以下检查和处理流程:

  • 体检和健康史:检查身体通用的健康标志,包括检查疾病标志,比如肿块或者其他不正常表征。也要检查病人之前的健康习惯,包括吸烟、工作环境、患过的疾病和治疗方法。
  • 实验室检测:对组织、血液、尿液或者体内其他物质的样品进行检验的医疗程序。这些检测有助于诊断疾病、安排治疗计划、检查治疗效果或者后续的疾病监测。
  • X线胸片:一种扫描胸部内部的器官和骨骼的X光片。x 射线是一种可以扫描全身,并且映射到胶片上的能量束,最终将身体内部的构造转变成图片。
  • 胸部x线检查。x射线被用来拍摄胸部器官和骨骼的照片。x射线穿过病人的身体,并将影像映射到胶片上。
  • 脑部,胸部及腹部CT扫描(CAT扫描):一种从不同的角度拍摄一系列身体内部区域详细图像的检查。图像通过一台与x射线机器相连的计算机生成的。显影剂可能会被注射入静脉或者被吞咽,使器官或组织更清楚地呈现。这种方法也被称为计算机体层摄影术,计算机断层扫描,或“计算机轴向断层扫描术”。
  • 痰细胞学:显微镜用于发现痰(从肺部咳出的粘液)中的癌细胞。
  • 活检:取出细胞或者组织,由病理医师在显微镜下观察并检查癌症迹象。活检的不同方式如下所示:
  • 肺部的细针穿刺(FNA)活检:用细针从肺部吸取肺部的组织或液体。可以用CT扫描、超声、或者其他成像方式对肺部的异常组织或液体进行定位。在皮肤上切开一个小的缺口,活检的针可以从这里插入到异常的组织或液体中。针吸出的一些样品被送至实验室。然后,病理学家便可通过显微镜观察样品,检查是否存在癌细胞。最后,要做一个x 胸片来确保没有气体从肺部泄露到胸腔内。
  • 肺部细针穿刺活检。病人躺在一张可以穿过计算机断层扫描(CT)仪的检查台上,CT扫描仪可以拍摄身体内部的x光片。x光片帮助医生看清楚肺异常组织的位置。活检针穿过胸腔壁,插入异常的肺组织区域。通过针取出一小片组织,在显微镜下检查是否有癌症迹象。
  • 支气管镜检:通过观察肺部气管和大气道寻找异常区域的过程。将支气管镜通过鼻子或者口腔插入气管以及肺部。支气管镜是一种细管状仪器,上面带有一个镜头和一个光源以便观察。它可能也包含切除组织的工具,取出的组织要在显微镜下进行检查,以寻找癌症的迹象。
  • 支气管镜检。支气管镜通过口腔、气管和主支气管插入肺内,以寻找异常区域。支气管镜是一种细管状仪器,上面带有一个镜头和一个光源以便观察。它也可能带有切除组织的工具。取出的组织要在显微镜下进行检查,以寻找疾病的迹象。
  • 胸腔镜检查:一种用以检查胸腔内部器官异常区域的外科手术操作。在两个肋骨之间切开一个切口(开口),将胸腔镜插入胸腔内部。胸腔镜是一个细管状的仪器,上面带有一个镜头和光源以便观察。其也包含切除组织或者淋巴结样品的工具,取出的组织要在显微镜下进行检查,以寻找癌症的迹象。在有些情况下,这种方法也可以用来移除部分的食管或者肺。如果无法到达特定的组织、器官或者淋巴结,那就要进行开胸手术。在这个过程中,肋骨间要切开一个大的切口,并且需打开胸腔。
  • 胸腔穿刺术:用穿刺针抽取胸腔内壁与肺部之间的液体。病理学家在显微镜下对液体样品观察,寻找癌症细胞。
  • 纵膈镜检查术:检查肺部之间的器官、组织和淋巴结的异常区域的一种外科手术操作。在胸骨的顶端切开一个切口,将纵膈镜由此插入到胸部中。纵膈镜是呈细管状的一种设备,上面带有一个光源和一个镜头以便观察。它也可能带有一个可以移除组织或者淋巴结样品的工具,取出的组织要在显微镜下进行检查,以寻找癌症的迹象。
  • 光学及电子显微镜检查法:一种使用常规及高倍显微镜观察组织样本中的细胞以寻找细胞中的某些改变的实验室检查法。
  • 免疫组织化学检测:用抗体检查病人组织样本中某些抗原(标记物)的实验室检查。抗体通常与酶或荧光染料相连。抗体与组织样本中的特定抗原结合后,酶或染色剂被激活,然后在显微镜下可以看到抗原。这种类型的检测被用来辅助诊断癌症,并帮助区分不同类型的癌症。
  • 某些因素影响预后(康复的可能性)以及治疗选项。

    预后(复发的几率)和治疗方案取决于以下因素:

  • 癌症分期(肿瘤大小以及是否只局限于肺部,或者已经蔓延到身体其他地方)。
  • 患者的年龄,性别以及总体健康状况。
  • 对于某些患者而言,预后也取决于患者是否接受化学疗法和放射疗法两种疗法。

    对大多数的小细胞肺癌患者来说,目前的治疗方案并不能治愈癌症。

    如果肺癌被发现,患者应考虑参加一项旨在改善治疗的临床试验。目前国家许多地区正在开展面向各种分期的小细胞肺癌患者的临床试验。关于正在进行的临床试验的信息可从NCI的网页中获得。

    Small Cell Lung Cancer Treatment (PDQ®)

    General Information About Small Cell Lung Cancer

    Small cell lung cancer is a disease in which malignant (cancer) cells form in the tissues of the lung.

    The lungs are a pair of cone-shaped breathing organs that are found in the chest. The lungs bring oxygen into the body when you breathe in and take out carbon dioxide when you breathe out. Each lung has sections called lobes. The left lung has two lobes. The right lung, which is slightly larger, has three. A thin membrane called the pleura surrounds the lungs. Two tubes called bronchi lead from the trachea (windpipe) to the right and left lungs. The bronchi are sometimes also affected by lung cancer. Small tubes called bronchioles and tiny air sacs called alveoli make up the inside of the lungs.

    Anatomy of the respiratory system, showing the trachea and both lungs and their lobes and airways. Lymph nodes and the diaphragm are also shown. Oxygen is inhaled into the lungs and passes through the thin membranes of the alveoli and into the bloodstream (see inset).

    There are two types of lung cancer: small cell lung cancer and non-small cell lung cancer.

    This summary is about small cell lung cancer and its treatment. See the following PDQ summaries for more information about lung cancer:

  • Non-Small Cell Lung Cancer Treatment
  • Unusual Cancers of Childhood Treatment
  • Lung Cancer Prevention
  • Lung Cancer Screening
  • There are two main types of small cell lung cancer.

    These two types include many different types of cells. The cancer cells of each type grow and spread in different ways. The types of small cell lung cancer are named for the kinds of cells found in the cancer and how the cells look when viewed under a microscope:

  • Small cell carcinoma (oat cell cancer).
  • Combined small cell carcinoma.
  • Smoking is the major risk factor for small cell lung cancer.

    Anything that increases your chance of getting a disease is called a risk factor. Having a risk factor does not mean that you will get cancer; not having risk factors doesn't mean that you will not get cancer. Talk to your doctor if you think you may be at risk for lung cancer.

    Risk factors for lung cancer include the following:

  • Smoking cigarettes, pipes, or cigars, now or in the past. This is the most important risk factor for lung cancer. The earlier in life a person starts smoking, the more often a person smokes, and the more years a person smokes, the greater the risk of lung cancer.
  • Being exposed to secondhand smoke.
  • Being exposed to asbestos, arsenic, chromium, beryllium, nickel, soot, or tar in the workplace.
  • Being exposed to radiation from any of the following:
  • Radiation therapy to the breast or chest.
  • Radon in the home or workplace.
  • Imaging tests such as CT scans.
  • Atomic bomb radiation.
  • Living where there is air pollution.
  • Having a family history of lung cancer.
  • Being infected with the human immunodeficiency virus (HIV).
  • Taking beta carotene supplements and being a heavy smoker.
  • Older age is the main risk factor for most cancers. The chance of getting cancer increases as you get older.

    When smoking is combined with other risk factors, the risk of lung cancer is increased.

    Signs and symptoms of small cell lung cancer include coughing, shortness of breath, and chest pain.

    These and other signs and symptoms may be caused by small cell lung cancer or by other conditions. Check with your doctor if you have any of the following:

  • Chest discomfort or pain.
  • A cough that doesn’t go away or gets worse over time.
  • Trouble breathing.
  • Wheezing.
  • Blood in sputum (mucus coughed up from the lungs).
  • Hoarseness.
  • Trouble swallowing.
  • Loss of appetite.
  • Weight loss for no known reason.
  • Feeling very tired.
  • Swelling in the face and/or veins in the neck.
  • Tests and procedures that examine the lungs are used to detect (find), diagnose, and stage small cell lung cancer.

    The following tests and procedures may be used:

  • Physical exam and history: An exam of the body to check general signs of health, including checking for signs of disease, such as lumps or anything else that seems unusual. A history of the patient’s health habits, including smoking, and past jobs, illnesses, and treatments will also be taken.
  • Laboratory tests: Medical procedures that test samples of tissue, blood, urine, or other substances in the body. These tests help to diagnose disease, plan and check treatment, or monitor the disease over time.
  • Chest x-ray: An x-ray of the organs and bones inside the chest. An x-ray is a type of energy beam that can go through the body and onto film, making a picture of areas inside the body.
  • X-ray of the chest. X-rays are used to take pictures of organs and bones of the chest. X-rays pass through the patient onto film.
  • CT scan (CAT scan) of the brain, chest, and abdomen: A procedure that makes a series of detailed pictures of areas inside the body, taken from different angles. The pictures are made by a computer linked to an x-ray machine. A dye may be injected into a vein or swallowed to help the organs or tissues show up more clearly. This procedure is also called computed tomography, computerized tomography, or computerized axial tomography.
  • Sputum cytology: A microscope is used to check for cancer cells in the sputum (mucus coughed up from the lungs).
  • Biopsy: The removal of cells or tissues so they can be viewed under a microscope by a pathologist to check for signs of cancer. The different ways a biopsy can be done include the following:
  • Fine-needle aspiration (FNA) biopsy of the lung: The removal of tissue or fluid from the lung, using a thin needle. A CT scan, ultrasound, or other imaging procedure is used to find the abnormal tissue or fluid in the lung. A small incision may be made in the skin where the biopsy needle is inserted into the abnormal tissue or fluid. A sample is removed with the needle and sent to the laboratory. A pathologist then views the sample under a microscope to look for cancer cells. A chest x-ray is done after the procedure to make sure no air is leaking from the lung into the chest.
  • Fine-needle aspiration biopsy of the lung. The patient lies on a table that slides through the computed tomography (CT) machine, which takes x-ray pictures of the inside of the body. The x-ray pictures help the doctor see where the abnormal tissue is in the lung. A biopsy needle is inserted through the chest wall and into the area of abnormal lung tissue. A small piece of tissue is removed through the needle and checked under the microscope for signs of cancer.
  • Bronchoscopy: A procedure to look inside the trachea and large airways in the lung for abnormal areas. A bronchoscope is inserted through the nose or mouth into the trachea and lungs. A bronchoscope is a thin, tube-like instrument with a light and a lens for viewing. It may also have a tool to remove tissue samples, which are checked under a microscope for signs of cancer.
  • Bronchoscopy. A bronchoscope is inserted through the mouth, trachea, and major bronchi into the lung, to look for abnormal areas. A bronchoscope is a thin, tube-like instrument with a light and a lens for viewing. It may also have a cutting tool. Tissue samples may be taken to be checked under a microscope for signs of disease.
  • Thoracoscopy: A surgical procedure to look at the organs inside the chest to check for abnormal areas. An incision (cut) is made between two ribs, and a thoracoscope is inserted into the chest. A thoracoscope is a thin, tube-like instrument with a light and a lens for viewing. It may also have a tool to remove tissue or lymph node samples, which are checked under a microscope for signs of cancer. In some cases, this procedure is used to remove part of the esophagus or lung. If certain tissues, organs, or lymph nodes can’t be reached, a thoracotomy may be done. In this procedure, a larger incision is made between the ribs and the chest is opened.
  • Thoracentesis: The removal of fluid from the space between the lining of the chest and the lung, using a needle. A pathologist views the fluid under a microscope to look for cancer cells.
  • Mediastinoscopy: A surgical procedure to look at the organs, tissues, and lymph nodes between the lungs for abnormal areas. An incision (cut) is made at the top of the breastbone and a mediastinoscope is inserted into the chest. A mediastinoscope is a thin, tube-like instrument with a light and a lens for viewing. It may also have a tool to remove tissue or lymph node samples, which are checked under a microscope for signs of cancer.
  • Light and electron microscopy: A laboratory test in which cells in a sample of tissue are viewed under regular and high-powered microscopes to look for certain changes in the cells.
  • Immunohistochemistry: A laboratory test that uses antibodies to check for certain antigens (markers) in a sample of a patient’s tissue. The antibodies are usually linked to an enzyme or a fluorescent dye. After the antibodies bind to a specific antigen in the tissue sample, the enzyme or dye is activated, and the antigen can then be seen under a microscope. This type of test is used to help diagnose cancer and to help tell one type of cancer from another type of cancer.
  • Certain factors affect prognosis (chance of recovery) and treatment options.

    The prognosis (chance of recovery) and treatment options depend on the following:

  • The stage of the cancer (whether it is in the chest cavity only or has spread to other places in the body).
  • The patient’s age, gender, and general health.
  • For certain patients, prognosis also depends on whether the patient is treated with both chemotherapy and radiation.

    For most patients with small cell lung cancer, current treatments do not cure the cancer.

    If lung cancer is found, patients should think about taking part in one of the many clinical trials being done to improve treatment. Clinical trials are taking place in most parts of the country for patients with all stages of small cell lung cancer. Information about ongoing clinical trials is available from the NCI website.

    小细胞肺癌的治疗(PDQ®)

    小细胞肺癌的不同分期

    在小细胞肺癌被诊断之后,将进行检查,查明癌细胞是否在胸腔内扩散,或者已扩散至身体其他部位。

    确定癌细胞是否在肺内或身体其他部位扩散的过程称为分期。在分期过程中收集的信息最终决定疾病的分期。为了制定治疗计划,了解分期是很重要的。一些用于诊断非小细胞肺癌的检测也用于分期。(请参阅“常用信息”部分。)

    在分期过程中可能使用的其他检测及程序包括:

  • MRI(磁共振成像):是使用磁体、无线电波和计算机产生一系列身体内部区域的详细图片的过程,例如大脑。这个过程也被称为核磁共振成像(NMRI)。
  • CT扫描(CAT扫描):一种从不同角度拍摄一系列身体内部区域详细的图像,如脑部,胸部或上腹部的方法。图像是由一台连接到x光机的计算机生成的。通过静脉注射或吞服显影剂,可使器官或组织更清楚地展示。这种方法也被称为计算机断层扫描,计算机化断层显像,或计算机化x射线轴向断层造影。
  • PET扫描(正电子发射断层扫描):一种用于发现体内恶性肿瘤细胞的方法。注射少量带有放射性的葡萄糖(糖)到静脉中。PET扫描仪绕着身体周围旋转,对于体内含有葡萄糖的部分进行成像。在图像中,由于恶性肿瘤细胞活性更高,和正常细胞比起来会吸收更多的葡萄糖,所以成像的亮度更高。这被检查方法称为PET-CT。
  • 骨扫描:一项检查骨骼中是否存在快速分裂的细胞(如癌细胞)的检测方法。微量的放射性物质被注射进静脉并通过血液循环转移到全身。在骨骼的癌症病灶中聚集的放射性物质会被扫描仪检测出来。
  • 癌症在体内有三种扩散方式。

    癌细胞可通过组织,淋巴系统以及血液扩散:

  • 组织。癌症从原发处扩散到邻近组织中。
  • 淋巴系统。癌组织从原发处侵入淋巴系统。癌细胞通过淋巴管可扩散到身体其他部位。
  • 血液。癌细胞从它发生的地方进入血液进行扩散。癌细胞从血管转移到人体其他部位。
  • 癌细胞可以从它发生的地方扩散到人体其他部位。

    癌症转移是指癌症扩散至身体其他部位。癌细胞从原发处(原发性肿瘤)脱离,侵入淋巴系统或血液。

  • 淋巴系统。癌组织侵入淋巴系统后,通过淋巴管在身体另一部位形成肿瘤(转移性肿瘤)。
  • 血液。癌组织侵入血液后,通过血液循环在身体另一部位形成肿瘤(转移性肿瘤)。
  • 转移性肿瘤与原发性肿瘤类型相同。例如,如果非小细胞肺癌扩散至大脑,则脑中的癌细胞实际上仍为肺癌细胞。该病应称为转移性肺癌,而非脑癌。

    许多癌症死亡是由于癌细胞从原发肿瘤扩散到其他组织和器官。这被称为转移癌。这个动画展示了癌细胞是如何从体内最初形成的位置转移到身体的其他部位的。

    小细胞肺癌的分期如下:

    局限期小细胞肺癌

    在局限期,恶性肿瘤在最初出现在肺部的地方,可能已经扩散到肺部之间的区域,或者扩散到锁骨以上的淋巴结。

    广泛期小细胞肺癌

    在广泛期,恶性肿瘤已扩散至超过肺部的区域,或肺部之间的区域,或锁骨以上的淋巴结,进入 身体其他部位。

    Small Cell Lung Cancer Treatment (PDQ®)

    Stages of Small Cell Lung Cancer

    After small cell lung cancer has been diagnosed, tests are done to find out if cancer cells have spread within the chest or to other parts of the body.

    The process used to find out if cancer has spread within the chest or to other parts of the body is called staging. The information gathered from the staging process determines the stage of the disease. It is important to know the stage in order to plan treatment. Some of the tests used to diagnose small cell lung cancer are also used to stage the disease. (See the General Information section.)

    Other tests and procedures that may be used in the staging process include the following:

  • MRI (magnetic resonance imaging) of the brain: A procedure that uses a magnet, radio waves, and a computer to make a series of detailed pictures of areas inside the body. This procedure is also called nuclear magnetic resonance imaging (NMRI).
  • CT scan (CAT scan): A procedure that makes a series of detailed pictures of areas inside the body, such as the brain, chest or upper abdomen, taken from different angles. The pictures are made by a computer linked to an x-ray machine. A dye may be injected into a vein or swallowed to help the organs or tissues show up more clearly. This procedure is also called computed tomography, computerized tomography, or computerized axial tomography.
  • PET scan (positron emission tomography scan): A procedure to find malignant tumor cells in the body. A small amount of radioactive glucose (sugar) is injected into a vein. The PET scanner rotates around the body and makes a picture of where glucose is being used in the body. Malignant tumor cells show up brighter in the picture because they are more active and take up more glucose than normal cells do. A PET scan and CT scan may be done at the same time. This is called a PET-CT.
  • Bone scan: A procedure to check if there are rapidly dividing cells, such as cancer cells, in the bone. A very small amount of radioactive material is injected into a vein and travels through the bloodstream. The radioactive material collects in the bones with cancer and is detected by a scanner.
  • There are three ways that cancer spreads in the body.

    Cancer can spread through tissue, the lymph system, and the blood:

  • Tissue. The cancer spreads from where it began by growing into nearby areas.
  • Lymph system. The cancer spreads from where it began by getting into the lymph system. The cancer travels through the lymph vessels to other parts of the body.
  • Blood. The cancer spreads from where it began by getting into the blood. The cancer travels through the blood vessels to other parts of the body.
  • Cancer may spread from where it began to other parts of the body.

    When cancer spreads to another part of the body, it is called metastasis. Cancer cells break away from where they began (the primary tumor) and travel through the lymph system or blood.

  • Lymph system. The cancer gets into the lymph system, travels through the lymph vessels, and forms a tumor (metastatic tumor) in another part of the body.
  • Blood. The cancer gets into the blood, travels through the blood vessels, and forms a tumor (metastatic tumor) in another part of the body.
  • The metastatic tumor is the same type of cancer as the primary tumor. For example, if small cell lung cancer spreads to the brain, the cancer cells in the brain are actually lung cancer cells. The disease is metastatic small cell lung cancer, not brain cancer.

    Many cancer deaths are caused when cancer moves from the original tumor and spreads to other tissues and organs. This is called metastatic cancer. This animation shows how cancer cells travel from the place in the body where they first formed to other parts of the body.

    The following stages are used for small cell lung cancer:

    Limited-Stage Small Cell Lung Cancer

    In limited-stage, cancer is in the lung where it started and may have spread to the area between the lungs or to the lymph nodes above the collarbone.

    Extensive-Stage Small Cell Lung Cancer

    In extensive-stage, cancer has spread beyond the lung or the area between the lungs or the lymph nodes above the collarbone to other places in the body.

    小细胞肺癌的治疗(PDQ®)

    复发性小细胞肺癌

    复发性小细胞肺癌是在被治愈之后复发的一种癌症。肿瘤可在胸部、中枢神经系统以及身体其他部位复发。

    Small Cell Lung Cancer Treatment (PDQ®)

    Recurrent Small Cell Lung Cancer

    Recurrent small cell lung cancer is cancer that has recurred (come back) after it has been treated. The cancer may come back in the chest, central nervous system, or in other parts of the body.

    小细胞肺癌的治疗(PDQ®)

    治疗方案概述

    对于患小细胞肺癌的患者,有不同类型的治疗方案。

    有不同类型的治疗方案可供小细胞肺癌患者选择。一些治疗方法是标准方法(当前使用的疗法),还有一些正在进行临床试验。治疗方法临床试验是一项研究,旨在帮助改善现有的治疗方法或获取有关癌症患者的新治疗方法的信息。当临床试验表明,新的治疗方法比标准疗法更好时,新的治疗方法可能成为标准疗法。患者可能考虑参加临床试验。一些临床试验只对未开始治疗的患者开放。

    目前正在使用六种标准治疗方法:

    手术

    如果只在一个肺或和临近的淋巴结中发现癌症,可以采用手术治疗。因为这种类型的肺癌通常在两个肺中发现,单独手术治疗的方法并不常采用。手术期间,医生还会切除淋巴结,检查里面是否有癌细胞。手术有时还用于获取肺组织样本,以确定肺癌的具体类型。

    手术时医生切除所能看到的所有癌症病灶后,一些病人可能会在手术后接受化疗或放疗,以杀死任何可能残留的癌细胞。手术后给予的治疗,用以降低癌症复发的风险,被称为辅助治疗。

    化疗

    化学疗法是使用药物阻止癌细胞的生长,杀死癌细胞或者是阻止细胞分裂的一种癌症治疗方法。化疗药物可通过口服,静脉注射或者是肌肉注射的方式,进入到血液中,并可到达全身的癌细胞(全身化疗)。当化疗药物直接进入脑脊液、器官或者是体腔(例如腹腔)时,药物主要影响这些区域的癌细胞(局部化疗)。采用何种化疗方法取决于接受治疗的癌症类型及癌症分期。

    关于更多信息,请参阅小细胞肺癌的药物批准。

    放射治疗

    放射治疗是一种癌症治疗方法,使用高能x射线或其他类型的辐射杀死癌细胞或阻止癌细胞生长。放射治疗有两种类型:

  • 体外放射治疗是利用体外的机器将辐射发送到癌症部位。
  • 体内放射治疗把一种放射性物质密封在针、种子、金属丝、或导管中,直接放置在癌症病灶中或病灶附近。
  • 放射治疗的方式取决于癌症的分型和分期。体外放射治疗用于治疗小细胞肺癌,也可作为姑息性治疗,以减轻症状和改善生活质量。也可以对大脑进行放射治疗,以降低癌症扩散到大脑的风险。

    免疫治疗

    免疫治疗是一种利用病人的免疫系统对抗癌症的疗法。人体产生或实验室制备的物质用于增强、引导或恢复人体对癌症的天然防御。这种癌症治疗也被称为生物治疗。

    免疫检查点抑制剂治疗是一种免疫治疗:

  • 免疫检查点抑制剂治疗:某些类型的免疫细胞如T细胞,和一些癌细胞的表面有某些蛋白,称为检查点蛋白,可以控制免疫反应。当癌细胞有大量的这些蛋白时,它们不会被T细胞攻击和杀死。免疫检查点抑制剂阻断这些蛋白进而T细胞杀死癌细胞的能力增加。它们被用来治疗一些晚期小细胞肺癌的患者。
  • 有两种类型的免疫检查点抑制剂治疗:

  • CTLA-4抑制剂:CTLA-4是T细胞表面的一种蛋白质,有助于控制身体的免疫反应。当CTLA-4结合到癌细胞上的另一种被称作B7的蛋白质上时,它会阻止T细胞杀死癌细胞。CTLA-4抑制剂结合到CTLA-4上,允许T细胞杀死癌细胞。伊匹单抗是一种CTLA-4抑制剂。
  • 免疫检查点抑制剂。检查点蛋白,如抗原呈递细胞(APC)上的B7-1/B7-2和T细胞上的CTLA-4,有助于控制身体的免疫反应。当T细胞受体(TCR)与APC上的抗原和主要组织相容性复合物(MHC)蛋白结合,CD28与APC上的B7-1/B7-2结合时,T细胞被激活。然而,B7-1/B7-2与CTLA-4的结合使T细胞处于失活状态,因此它们不能杀死体内的肿瘤细胞(左图)。用免疫检查点抑制剂(抗CTLA-4抗体)阻断B7-1/B7-2与CTLA-4的结合,激活T细胞并杀死肿瘤细胞(右图)。
  • PD-1抑制剂:PD-1是一种位于T细胞表面的蛋白质,有助于控制人体的免疫反应。当PD-1结合到癌细胞上的另一种叫做PDL-1的蛋白质上时,它会阻止T细胞杀死癌细胞。PD-1抑制剂结合到PDL-1上,使T细胞杀死癌细胞。派姆单抗和纳武单抗是两种PD-1抑制剂。
  • 免疫检查点抑制剂。肿瘤细胞上的PD-L1和T细胞上的PD-1等检查点蛋白有助于抑制免疫反应。PD-L1与PD-1的结合阻止了T细胞杀死体内的肿瘤细胞(左图)。用免疫检查点抑制剂(抗PD-L1或抗PD-1)阻断PD-L1与PD-1的结合,使T细胞能够杀死肿瘤细胞(右图)。
    免疫治疗利用人体的免疫系统来对抗癌症。这个动画解释了一种使用免疫检查点抑制剂来治疗癌症的免疫治疗。

    关于更多信息,请参阅小细胞肺癌的药物批准。

    激光治疗

    激光治疗是利用激光束(一种窄束强光)来杀死癌细胞。

    内窥镜支架放置术

    内窥镜是一种细的、管状仪器,用于观察人体内部的组织。内窥镜有光源及用于观测的镜头,可能用于在身体结构内放置一个支架来保持结构张开。内窥镜支架也可用于打开被异常组织阻塞的气道。

    新型疗法正处于临床试验的测试阶段。

    有关临床试验的信息可从NCI网站上获得。

    小细胞肺癌的治疗可能会引起副作用。

    有关癌症治疗的副作用的信息,请参阅我们的副作用页面。

    患者可能会考虑加入到临床试验中。

    对一些患者来说,参加临床试验或许是最佳的治疗选择。临床试验是癌症研究过程的一部分。临床试验的目的是为了确定新疗法是否安全有效或优于标准疗法。

    很多现在的标准疗法都是基于以前的临床试验结果。参与临床试验的患者可能接受标准治疗,也可能最先接受新疗法。

    参加临床试验的患者还能帮助改善癌症未来的治疗方式。即使未能研究出有效的新疗法,临床试验也常常能解决一些重要的问题,推进研究。

    患者可以在开始癌症治疗之前、期间或之后进入临床试验。

    有些临床试验只允许未经治疗的患者参加。有些试验针对病情未好转的癌症患者。还有一些临床试验旨在研究新的措施来防止癌症复发(再次发作)或减少癌症治疗副作用。

    临床试验正在全国许多地方进行。有关NCI支持的临床试验的信息可在NCI的临床试验搜索网站上找到。其他组织支持的临床试验可以在ClinicalTrials.gov网站上找到。

    可能需要后续检查

    确诊癌症或确定其分期可能需要重复检查。为判断治疗效果也应多次检查。这些检查结果会决定是否需要继续治疗、或改变治疗方案。

    在治疗结束后,还会持续的做一些检查。这些检查的结果可以表明你的健康状况是否发生改变,或者癌症是否复发(再发)。这些检查被叫做随访检查或者复查。

    Small Cell Lung Cancer Treatment (PDQ®)

    Treatment Option Overview

    There are different types of treatment for patients with small cell lung cancer.

    Different types of treatment are available for patients with small cell lung cancer. Some treatments are standard (the currently used treatment), and some are being tested in clinical trials. A treatment clinical trial is a research study meant to help improve current treatments or obtain information on new treatments for patients with cancer. When clinical trials show that a new treatment is better than the standard treatment, the new treatment may become the standard treatment. Patients may want to think about taking part in a clinical trial. Some clinical trials are open only to patients who have not started treatment.

    Six types of standard treatment are used:

    Surgery

    Surgery may be used if the cancer is found in one lung and in nearby lymph nodes only. Because this type of lung cancer is usually found in both lungs, surgery alone is not often used. During surgery, the doctor will also remove lymph nodes to find out if they have cancer in them. Sometimes, surgery may be used to remove a sample of lung tissue to find out the exact type of lung cancer.

    After the doctor removes all the cancer that can be seen at the time of the surgery, some patients may be given chemotherapy or radiation therapy after surgery to kill any cancer cells that are left. Treatment given after the surgery, to lower the risk that the cancer will come back, is called adjuvant therapy.

    Chemotherapy

    Chemotherapy is a cancer treatment that uses drugs to stop the growth of cancer cells, either by killing the cells or by stopping them from dividing. When chemotherapy is taken by mouth or injected into a vein or muscle, the drugs enter the bloodstream and can reach cancer cells throughout the body (systemic chemotherapy). When chemotherapy is placed directly into the cerebrospinal fluid, an organ, or a body cavity such as the abdomen, the drugs mainly affect cancer cells in those areas (regional chemotherapy). The way the chemotherapy is given depends on the type and stage of the cancer being treated.

    See Drugs Approved for Small Cell Lung Cancer for more information.

    Radiation therapy

    Radiation therapy is a cancer treatment that uses high-energy x-rays or other types of radiation to kill cancer cells or keep them from growing. There are two types of radiation therapy:

  • External radiation therapy uses a machine outside the body to send radiation toward the cancer.
  • Internal radiation therapy uses a radioactive substance sealed in needles, seeds, wires, or catheters that are placed directly into or near the cancer.
  • The way the radiation therapy is given depends on the type and stage of the cancer being treated. External radiation therapy is used to treat small cell lung cancer, and may also be used as palliative therapy to relieve symptoms and improve quality of life. Radiation therapy to the brain to lessen the risk that cancer will spread to the brain may also be given.

    Immunotherapy

    Immunotherapy is a treatment that uses the patient's immune system to fight cancer. Substances made by the body or made in a laboratory are used to boost, direct, or restore the body's natural defenses against cancer. This type of cancer treatment is also called biotherapy or biologic therapy.

    Immune checkpoint inhibitor therapy is a type of immunotherapy:

  • Immune checkpoint inhibitor therapy: Some types of immune cells, such as T cells, and some cancer cells have certain proteins, called checkpoint proteins, on their surface that keep immune responses in check. When cancer cells have large amounts of these proteins, they will not be attacked and killed by T cells. Immune checkpoint inhibitors block these proteins and the ability of T cells to kill cancer cells is increased. They are used to treat some patients with advanced small-cell lung cancer.
  • There are two types of immune checkpoint inhibitor therapy:

  • CTLA-4 inhibitor: CTLA-4 is a protein on the surface of T cells that helps keep the body’s immune responses in check. When CTLA-4 attaches to another protein called B7 on a cancer cell, it stops the T cell from killing the cancer cell. CTLA-4 inhibitors attach to CTLA-4 and allow the T cells to kill cancer cells. Ipilimumab is a type of CTLA-4 inhibitor.
  • Immune checkpoint inhibitor. Checkpoint proteins, such as B7-1/B7-2 on antigen-presenting cells (APC) and CTLA-4 on T cells, help keep the body’s immune responses in check. When the T-cell receptor (TCR) binds to antigen and major histocompatibility complex (MHC) proteins on the APC and CD28 binds to B7-1/B7-2 on the APC, the T cell can be activated. However, the binding of B7-1/B7-2 to CTLA-4 keeps the T cells in the inactive state so they are not able to kill tumor cells in the body (left panel). Blocking the binding of B7-1/B7-2 to CTLA-4 with an immune checkpoint inhibitor (anti-CTLA-4 antibody) allows the T cells to be active and to kill tumor cells (right panel).
  • PD-1 inhibitor: PD-1 is a protein on the surface of T cells that helps keep the body’s immune responses in check. When PD-1 attaches to another protein called PDL-1 on a cancer cell, it stops the T cell from killing the cancer cell. PD-1 inhibitors attach to PDL-1 and allow the T cells to kill cancer cells. Pembrolizumab and nivolumab are types of PD-1 inhibitors.
  • Immune checkpoint inhibitor. Checkpoint proteins, such as PD-L1 on tumor cells and PD-1 on T cells, help keep immune responses in check. The binding of PD-L1 to PD-1 keeps T cells from killing tumor cells in the body (left panel). Blocking the binding of PD-L1 to PD-1 with an immune checkpoint inhibitor (anti-PD-L1 or anti-PD-1) allows the T cells to kill tumor cells (right panel).
    Immunotherapy uses the body’s immune system to fight cancer. This animation explains one type of immunotherapy that uses immune checkpoint inhibitors to treat cancer.

    See Drugs Approved for Small Cell Lung Cancer for more information.

    Laser therapy

    Laser therapy is a cancer treatment that uses a laser beam (a narrow beam of intense light) to kill cancer cells.

    Endoscopic stent placement

    An endoscope is a thin, tube-like instrument used to look at tissues inside the body. An endoscope has a light and a lens for viewing and may be used to place a stent in a body structure to keep the structure open. An endoscopic stent can be used to open an airway blocked by abnormal tissue.

    New types of treatment are being tested in clinical trials.

    Information about clinical trials is available from the NCI website.

    Treatment for small cell lung cancer may cause side effects.

    For information about side effects caused by treatment for cancer, see our Side Effects page.

    Patients may want to think about taking part in a clinical trial.

    For some patients, taking part in a clinical trial may be the best treatment choice. Clinical trials are part of the cancer research process. Clinical trials are done to find out if new cancer treatments are safe and effective or better than the standard treatment.

    Many of today's standard treatments for cancer are based on earlier clinical trials. Patients who take part in a clinical trial may receive the standard treatment or be among the first to receive a new treatment.

    Patients who take part in clinical trials also help improve the way cancer will be treated in the future. Even when clinical trials do not lead to effective new treatments, they often answer important questions and help move research forward.

    Patients can enter clinical trials before, during, or after starting their cancer treatment.

    Some clinical trials only include patients who have not yet received treatment. Other trials test treatments for patients whose cancer has not gotten better. There are also clinical trials that test new ways to stop cancer from recurring (coming back) or reduce the side effects of cancer treatment.

    Clinical trials are taking place in many parts of the country. Information about clinical trials supported by NCI can be found on NCI’s clinical trials search webpage. Clinical trials supported by other organizations can be found on the ClinicalTrials.gov website.

    Follow-up tests may be needed.

    Some of the tests that were done to diagnose the cancer or to find out the stage of the cancer may be repeated. Some tests will be repeated in order to see how well the treatment is working. Decisions about whether to continue, change, or stop treatment may be based on the results of these tests.

    Some of the tests will continue to be done from time to time after treatment has ended. The results of these tests can show if your condition has changed or if the cancer has recurred (come back). These tests are sometimes called follow-up tests or check-ups.

    小细胞肺癌的治疗(PDQ®)

    根据分期的治疗方案

    有关以下列出的治疗方法信息,请参阅治疗选择概述部分。

    局限期小细胞肺癌

    局限期小细胞肺癌的治疗方法如下所示:

  • 对胸部采用联合化疗及放射治疗的方法。完全缓解的患者以后可以进行脑部放疗。
  • 对于不能接受放疗的患者,可仅采用联合化疗。
  • 手术后化疗。
  • 术后化疗和放疗
  • 对于完全缓解的患者,可以给予脑部放疗,以防止癌症扩散到脑部。
  • 新的化疗、手术及放疗方法的临床试验。
  • 使用我们的临床试验搜索,您可以查找在NCI支持癌症临床试验中,有哪些目前正在招募患者。您可以根据癌症类型、患者年龄和试验地点,搜索临床试验。您还可以获得有关临床试验的基本信息。

    广泛期小细胞肺癌

    广泛期小细胞肺癌的治疗方法如下所示:

  • 联合化疗。
  • 对癌细胞已扩散至脑部、脊椎、骨骼或身体的其他部位的患者进行放疗,作为姑息性治疗,以减轻患者症状,改善生活质量。
  • 对化疗有反应的病人,可以给予胸部放疗。
  • 对于完全缓解的患者,可以给予脑部放疗,以防止癌症扩散到脑部。
  • 新的化疗方法或者新的免疫检查点抑制剂免疫治疗的临床试验
  • 使用我们的临床试验搜索,您可以查找在NCI支持癌症临床试验中,有哪些目前正在招募患者。您可以根据癌症类型、患者年龄和试验地点,搜索临床试验。您还可以获得有关临床试验的基本信息。

    Small Cell Lung Cancer Treatment (PDQ®)

    Treatment Options by Stage

    For information about the treatments listed below, see the Treatment Option Overview section.

    Limited-Stage Small Cell Lung Cancer

    Treatment of limited-stage small cell lung cancer may include the following:

  • Combination chemotherapy and radiation therapy to the chest. Radiation therapy to the brain may later be given to patients with complete responses.
  • Combination chemotherapy alone for patients who cannot be given radiation therapy.
  • Surgery followed by chemotherapy.
  • Surgery followed by chemotherapy and radiation therapy.
  • Radiation therapy to the brain may be given to patients who have had a complete response, to prevent the spread of cancer to the brain.
  • Clinical trials of new chemotherapy, surgery, and radiation treatments.
  • Use our clinical trial search to find NCI-supported cancer clinical trials that are accepting patients. You can search for trials based on the type of cancer, the age of the patient, and where the trials are being done. General information about clinical trials is also available.

    Extensive-Stage Small Cell Lung Cancer

    Treatment of extensive-stage small cell lung cancer may include the following:

  • Combination chemotherapy.
  • Radiation therapy to the brain, spine, bone, or other parts of the body where the cancer has spread, as palliative therapy to relieve symptoms and improve quality of life.
  • Radiation therapy to the chest may be given to patients who respond to chemotherapy.
  • Radiation therapy to the brain may be given to patients who have had a complete response, to prevent the spread of cancer to the brain.
  • Clinical trials of new treatments with chemotherapy or immunotherapy with immune checkpoint inhibitors.
  • Use our clinical trial search to find NCI-supported cancer clinical trials that are accepting patients. You can search for trials based on the type of cancer, the age of the patient, and where the trials are being done. General information about clinical trials is also available.

    小细胞肺癌的治疗(PDQ®)

    复发性小细胞肺癌的治疗选项

    有关以下列出的治疗方法信息,请参阅治疗选择概述部分。

    复发性小细胞肺癌的治疗包含以下方法:

  • 化疗。
  • 使用免疫检查点抑制剂的免疫治疗
  • 放疗作为一种姑息性治疗方法,用于改善症状,提高生活质量。
  • 激光治疗,支架置入术,以保持气道开放,和/或内部放射治疗作为姑息性治疗方法,用于缓解症状,改善生活质量。
  • 新型化疗方法的临床试验
  • 使用我们的临床试验搜索,您可以查找在NCI支持癌症临床试验中,有哪些目前正在招募患者。您可以根据癌症类型、患者年龄和试验地点,搜索临床试验。您还可以获得有关临床试验的基本信息。

    Small Cell Lung Cancer Treatment (PDQ®)

    Treatment Options for Recurrent Small Cell Lung Cancer

    For information about the treatments listed below, see the Treatment Option Overview section.

    Treatment of recurrent small cell lung cancer may include the following:

  • Chemotherapy.
  • Immunotherapy with immune checkpoint inhibitors.
  • Radiation therapy as palliative therapy to relieve symptoms and improve quality of life.
  • Laser therapy, stent placement to keep airways open, and/or internal radiation therapy as palliative therapy to relieve symptoms and improve quality of life.
  • Clinical trials of new chemotherapy treatments.
  • Use our clinical trial search to find NCI-supported cancer clinical trials that are accepting patients. You can search for trials based on the type of cancer, the age of the patient, and where the trials are being done. General information about clinical trials is also available.

    小细胞肺癌的治疗(PDQ®)

    以了解更多关于小细胞肺癌的信息

    更多来自国家癌症研究所的有关小细胞肺癌的信息,请参阅以下内容:

  • 肺癌主页
  • 肺癌预防
  • 肺癌筛查
  • 已批准的小细胞肺癌的治疗药物
  • 烟草(包括辅助戒烟)
  • 吸烟:健康风险以及如何戒烟
  • 二手烟和癌症
  • 如想了解国家癌症研究所发布的基本癌症信息和其他资源,请参阅以下内容:

  • 关于癌症
  • 癌症分期
  • 化疗与您:支持癌症患者
  • 放射治疗与你:支持癌症患者
  • 战胜癌症
  • 向医生询问关于癌症的问题
  • 幸存者和护理人员
  • Small Cell Lung Cancer Treatment (PDQ®)

    To Learn More About Small Cell Lung Cancer

    For more information from the National Cancer Institute about small cell lung cancer, see the following:

  • Lung Cancer Home Page
  • Lung Cancer Prevention
  • Lung Cancer Screening
  • Drugs Approved for Small Cell Lung Cancer
  • Tobacco (includes help with quitting)
  • Cigarette Smoking: Health Risks and How to Quit
  • Secondhand Smoke and Cancer
  • For general cancer information and other resources from the National Cancer Institute, see the following:

  • About Cancer
  • Staging
  • Chemotherapy and You: Support for People With Cancer
  • Radiation Therapy and You: Support for People With Cancer
  • Coping with Cancer
  • Questions to Ask Your Doctor about Cancer
  • For Survivors and Caregivers
  • 小细胞肺癌的治疗(PDQ®)

    About This PDQ Summary

    About PDQ

    Physician Data Query (PDQ) is the National Cancer Institute's (NCI's) comprehensive cancer information database. The PDQ database contains summaries of the latest published information on cancer prevention, detection, genetics, treatment, supportive care, and complementary and alternative medicine. Most summaries come in two versions. The health professional versions have detailed information written in technical language. The patient versions are written in easy-to-understand, nontechnical language. Both versions have cancer information that is accurate and up to date and most versions are also available in Spanish.

    PDQ is a service of the NCI. The NCI is part of the National Institutes of Health (NIH). NIH is the federal government’s center of biomedical research. The PDQ summaries are based on an independent review of the medical literature. They are not policy statements of the NCI or the NIH.

    Purpose of This Summary

    This PDQ cancer information summary has current information about the treatment of small cell lung cancer. It is meant to inform and help patients, families, and caregivers. It does not give formal guidelines or recommendations for making decisions about health care.

    Reviewers and Updates

    Editorial Boards write the PDQ cancer information summaries and keep them up to date. These Boards are made up of experts in cancer treatment and other specialties related to cancer. The summaries are reviewed regularly and changes are made when there is new information. The date on each summary ("Updated") is the date of the most recent change.

    The information in this patient summary was taken from the health professional version, which is reviewed regularly and updated as needed, by the PDQ Adult Treatment Editorial Board.

    Clinical Trial Information

    A clinical trial is a study to answer a scientific question, such as whether one treatment is better than another. Trials are based on past studies and what has been learned in the laboratory. Each trial answers certain scientific questions in order to find new and better ways to help cancer patients. During treatment clinical trials, information is collected about the effects of a new treatment and how well it works. If a clinical trial shows that a new treatment is better than one currently being used, the new treatment may become "standard." Patients may want to think about taking part in a clinical trial. Some clinical trials are open only to patients who have not started treatment.

    Clinical trials can be found online at NCI's website. For more information, call the Cancer Information Service (CIS), NCI's contact center, at 1-800-4-CANCER (1-800-422-6237).

    Permission to Use This Summary

    PDQ is a registered trademark. The content of PDQ documents can be used freely as text. It cannot be identified as an NCI PDQ cancer information summary unless the whole summary is shown and it is updated regularly. However, a user would be allowed to write a sentence such as “NCI’s PDQ cancer information summary about breast cancer prevention states the risks in the following way: [include excerpt from the summary].”

    The best way to cite this PDQ summary is:

    PDQ® Adult Treatment Editorial Board. PDQ Small Cell Lung Cancer Treatment. Bethesda, MD: National Cancer Institute. Updated . Available at: https://www.cancer.gov/types/lung/patient/small-cell-lung-treatment-pdq. Accessed . [PMID: 26389478]

    Images in this summary are used with permission of the author(s), artist, and/or publisher for use in the PDQ summaries only. If you want to use an image from a PDQ summary and you are not using the whole summary, you must get permission from the owner. It cannot be given by the National Cancer Institute. Information about using the images in this summary, along with many other images related to cancer can be found in Visuals Online. Visuals Online is a collection of more than 3,000 scientific images.

    Disclaimer

    The information in these summaries should not be used to make decisions about insurance reimbursement. More information on insurance coverage is available on Cancer.gov on the Managing Cancer Care page.

    Contact Us

    More information about contacting us or receiving help with the Cancer.gov website can be found on our Contact Us for Help page. Questions can also be submitted to Cancer.gov through the website’s E-mail Us.

    Small Cell Lung Cancer Treatment (PDQ®)

    About This PDQ Summary

    About PDQ

    Physician Data Query (PDQ) is the National Cancer Institute's (NCI's) comprehensive cancer information database. The PDQ database contains summaries of the latest published information on cancer prevention, detection, genetics, treatment, supportive care, and complementary and alternative medicine. Most summaries come in two versions. The health professional versions have detailed information written in technical language. The patient versions are written in easy-to-understand, nontechnical language. Both versions have cancer information that is accurate and up to date and most versions are also available in Spanish.

    PDQ is a service of the NCI. The NCI is part of the National Institutes of Health (NIH). NIH is the federal government’s center of biomedical research. The PDQ summaries are based on an independent review of the medical literature. They are not policy statements of the NCI or the NIH.

    Purpose of This Summary

    This PDQ cancer information summary has current information about the treatment of small cell lung cancer. It is meant to inform and help patients, families, and caregivers. It does not give formal guidelines or recommendations for making decisions about health care.

    Reviewers and Updates

    Editorial Boards write the PDQ cancer information summaries and keep them up to date. These Boards are made up of experts in cancer treatment and other specialties related to cancer. The summaries are reviewed regularly and changes are made when there is new information. The date on each summary ("Updated") is the date of the most recent change.

    The information in this patient summary was taken from the health professional version, which is reviewed regularly and updated as needed, by the PDQ Adult Treatment Editorial Board.

    Clinical Trial Information

    A clinical trial is a study to answer a scientific question, such as whether one treatment is better than another. Trials are based on past studies and what has been learned in the laboratory. Each trial answers certain scientific questions in order to find new and better ways to help cancer patients. During treatment clinical trials, information is collected about the effects of a new treatment and how well it works. If a clinical trial shows that a new treatment is better than one currently being used, the new treatment may become "standard." Patients may want to think about taking part in a clinical trial. Some clinical trials are open only to patients who have not started treatment.

    Clinical trials can be found online at NCI's website. For more information, call the Cancer Information Service (CIS), NCI's contact center, at 1-800-4-CANCER (1-800-422-6237).

    Permission to Use This Summary

    PDQ is a registered trademark. The content of PDQ documents can be used freely as text. It cannot be identified as an NCI PDQ cancer information summary unless the whole summary is shown and it is updated regularly. However, a user would be allowed to write a sentence such as “NCI’s PDQ cancer information summary about breast cancer prevention states the risks in the following way: [include excerpt from the summary].”

    The best way to cite this PDQ summary is:

    PDQ® Adult Treatment Editorial Board. PDQ Small Cell Lung Cancer Treatment. Bethesda, MD: National Cancer Institute. Updated . Available at: https://www.cancer.gov/types/lung/patient/small-cell-lung-treatment-pdq. Accessed . [PMID: 26389478]

    Images in this summary are used with permission of the author(s), artist, and/or publisher for use in the PDQ summaries only. If you want to use an image from a PDQ summary and you are not using the whole summary, you must get permission from the owner. It cannot be given by the National Cancer Institute. Information about using the images in this summary, along with many other images related to cancer can be found in Visuals Online. Visuals Online is a collection of more than 3,000 scientific images.

    Disclaimer

    The information in these summaries should not be used to make decisions about insurance reimbursement. More information on insurance coverage is available on Cancer.gov on the Managing Cancer Care page.

    Contact Us

    More information about contacting us or receiving help with the Cancer.gov website can be found on our Contact Us for Help page. Questions can also be submitted to Cancer.gov through the website’s E-mail Us.

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    目录
    章 节
    关于小细胞肺癌的基本信息 小细胞肺癌的不同分期 复发性小细胞肺癌 治疗方案概述 根据分期的治疗方案 复发性小细胞肺癌的治疗选项 以了解更多关于小细胞肺癌的信息 About This PDQ Summary